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ProteomicsHuman DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
To date few DDK substrates other than the MCM helicase have been identified, and none are implicated in fork protection or restart. Here we searched for such factors, using SILAC and quantitative mass spectrometry to identify the DDK phosphoproteome during fork stalling.
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD014399 | Pride
Lc-ms/ms Chemical genetics Cdc7 Ddk Stalled forks Analogue-sesitive Phosphoproteomics Replication 
ProteomicsMps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation
Spindle assembly checkpoint (SAC) regulators such as the Mps1 kinase not only delay anaphase onset, but also correct improper chromosome-spindle linkages that would otherwise lead to missegregation and aneuploidy. However, the substrates and mechanisms involved in this pathway of error correction re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006135 | Pride
Proteomics Mps1 Chemical genetics Ska complex Spindle assembly checkpoint (sac) Pp2a-b56 
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