Sort   by:  
 Page size 
ProteomicsProteomic profiling of FBXO11 protein complexes
FBXO11, a member of the F-box protein family, plays a critical role in cellular processes such as protein degradation, cell cycle regulation, and signaling pathways by serving as a substrate recognition component of the SKP1-Cullin-F-box (SCF) ubiquitin ligase complex. Dysregulation of FBXO11 has be...
ORGANISM(S): Homo sapiens (Human) 
2025-11-14 | PXD059844 | Pride
Proteomics Mass spectrometry Fbxo11 
UnknownCaspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.
Not available
S-EPMC7306001 | biostudies-literature
UnknownIdentification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.
Not available
S-EPMC5593168 | biostudies-literature
ProteomicsIntegrative Network Analysis Reveals USP7 Haploinsufficiency Inhibits E-protein Activity in Pediatric T-lineage Acute Lymphoblastic Leukemia (T-ALL)
USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene activation. Network analysis of >200 T-ALL tran...
ORGANISM(S): Homo sapiens (Human) 
2021-03-16 | PXD023377 | Pride
Tal1 T-all Usp7 
ProteomicsProteomics profiling of human CD34+ cells from MDS bone marrow and healthy control cells
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic disorders characterized by ineffective blood cell production and a high risk of progression to acute myeloid leukemia (AML). CD34+ hematopoietic stem and progenitor cells (HSPCs) play a critical role in the pathophysiology of...
ORGANISM(S): Homo sapiens (Human) 
2025-11-14 | PXD059857 | Pride
Dia proteomics Npm1 Myelodysplastic syndromes Leukemia Mds fbxo11 
UnknownIntegrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).
Not available
S-EPMC7933146 | biostudies-literature
UnknownTandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency.
Not available
S-EPMC12793833 | biostudies-literature
UnknownFBXO11 suppression rewires an NPM1-centered interactome influencing the progression of myelodysplastic syndrome.
Not available
S-EPMC12807477 | biostudies-literature
ProteomicsThe Histone Acetyltransferase MOZ is a Molecular Dependency and Therapeutic Target in NUP98-Rearranged Acute Myeloid Leukemia
NUP98 fusion oncoproteins (FOs) are a hallmark of childhood acute myeloid leukemia (AML), and drive leukemogenesis through liquid-liquid phase separation-mediated nuclear condensate formation. However, the composition and consequences of NUP98 FO-associated condensates are incompletely understood. H...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD058286 | Pride
Histone acetyltransferase Gene fusion Leukemia Nup98 
UnknownKAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia.
Not available
S-EPMC12498098 | biostudies-literature
Sort   by:  
 Page size