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UnknownEfficacy and safety of eptinezumab in patients with chronic migraine and medication-overuse headache: a randomized, double-blind, placebo-controlled study.
Not available
S-EPMC10722704 | biostudies-literature
UnknownPIONEER REAL Sweden: A Multicentre, Prospective, Real-World Observational Study of Oral Semaglutide Use in Adults with Type 2 Diabetes in Swedish Clinical Practice.
Not available
S-EPMC11330427 | biostudies-literature
ProteomicsRegulating hippocampal levels of Alzheimer´s disease-related proteins with a brain-penetrating somatostatin peptide
Plaques consisting of amyloid-β (Aβ) in the brain are characteristic for patients with Alzheimer´s disease. Aβ is enzymatically generated of the amyloid precursor protein. Furthermore, neprilysin, an Aβ-degrading enzyme, and its main activator the neuropeptide somatostatin (SST) are d...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD022221 | Pride
Alzheimerã‚â´s disease Tryptic digestion Brain Lc-ms Mice Neprilysin Sst-scfv8d3 Amyloid-ãžâ² 
ProteomicsWell-plate uFASP for proteomic analysis of single pancreatic islets
Filter-aided sample preparation (FASP) is widely used in bottom-up proteomics for tryptic digestion. However, the sample recovery yield of this method is limited by the amount of starting material. While ~100 ng of digested protein sample is sufficient for thorough protein identification, proteomic ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-04-01 | PXD029039 | Pride
Fasp Islets of langerhans Method development 
ProteomicsBrain proteome analysis of APPswe mouse model at the early stages of Alzheimer's disease pathology
Plaques consisting of amyloid-β (Aβ) in the brain are characteristic for patients with Alzheimer´s disease. Aβ is enzymatically generated of the amyloid precursor protein (APP). During the disease, Aβ starts to aggregate forming soluble oligomers, soluble protofibrils and eventually insoluble f...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD026566 | Pride
Tryptic digestion Brain Lc-ms Mice Alzheimer's disease 
ProteomicsSubzero hydrogen-deuterium exchange CE-MS
We have performed in solution hydrogen exchange (HDX) on peptide standards and bovine hemoglobin with subsequent quenching, pepsin digestion, and cold capillary electrophoretic separation coupled with mass spectrometry (MS) detection for the benchmarking of a lab built HDX-MS platform. Though neutra...
ORGANISM(S): Bos taurus (Bovine) 
2022-12-22 | PXD034245 | Pride
Ce-ms Hdx Hemoglobin 
ProteomicsRNA interactome capture in Escherichia coli globally identifies RNA-binding proteins
RNA-binding proteins (RPBs) are deeply involved in many fundamental cellular processes in bacteria and are vital for their survival. Despite this, few studies have so far been dedicated to globally identifying bacterial RBPs. We have adapted the RNA interactome capture (RIC) technique, originally de...
ORGANISM(S): Escherichia coli 
2023-03-30 | PXD032939 | Pride
Lc-ms Rna interactome capture Escherichia coli 
ProteomicsEffects of pro-opiomelanocortin neuropeptides on immunological pathways mediated by the melanocortin 3 receptor revealed by label-free quantitative thermal proteome profiling
In a thermal proteome profiling experiment we have identified 300 unique proteins that become thermally stabilized or destabilized downstream of signal activation of the melanocortin 3 receptor (MC3R) when expressed in HEK293 cells. Upon stimulation with either one of the endogenous MC3R-agonists AC...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039945 | Pride
Mc3r Tpp Label-free quantitation Pomc 
TranscriptomicsScreening for copy-number alterations and LOH in CLL - a comparative study of four microarray platforms
Screening for gene copy-number alterations (CNAs) has improved by applying genome-wide microarrays, where SNP arrays also allow analysis of loss of heterozygozity (LOH). We here analyzed 10 chronic lymphocytic leukemia (CLL) samples using four different high-resolution platforms: BAC arrays (32K), o...
ORGANISM(S): Homo sapiens 
2008-12-10 | E-GEOD-13557 | biostudies-arrayexpress
ProteomicsGABA, glucose and insulin orchestrate CD4+ T cells effector functions
Metabolic programs of immune cells are closely linked to their effector functions , where physiological molecules provide environmental cues and guidance. Exactly how it happens is still being unraveled. Insulin maintains normal blood glucose levels and glucose is themain source of energy and a prec...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD041654 | Pride
Cd4 Gaba 
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