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ProteomicsRAB GTPase proximity interactome
RAB GTPases represent the most abundant family of small GTPases and regulate multiple aspects of membrane trafficking events, from cargo sorting to vesicle budding, transport, docking, and fusion. To control these processes, RABs are tightly regulated by guanine exchange factors (GEFs) and GTPase-ac...
ORGANISM(S): Homo sapiens (Human) 
2025-12-02 | PXD057404 | Pride
Rab gtpase Apex2 Membrane trafficking Bioid 
ProteomicsAn early endosomal network participates to enterocyte functions and intestinal homeostasis
Membrane trafficking is defined as the vesicular transport of molecules throughout the cell. In intestinal enterocytes, defects in endocytic/recycling pathways impair their function and are linked to genetic diseases. How does trafficking regulate intestinal tissue homeostasis is poorly understood. ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-08-12 | PXD022413 | Pride
Intestine Tmt Drosophila Rab21 
Proteomics4 RABs proxymity labelling - APEX2-mediated RAB proximity labeling identifies a role for RAB21 in clathrin-independent cargo sorting
APEX2-mediated proximity labeling was performed with 4 endosomal RABs allowed an efficient and comprehensive identification of their protein neighbors. APEX2-mediated proximity labeling was performed in triplicate. Protein enrichments obtained from all RABs were compared to APEX2-nude proximity labe...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010950 | Pride
Early endosomes Apex2 Rabs Membrane trafficking 
UnknownA deletion in the N gene of SARS-CoV-2 may reduce test sensitivity for detection of SARS-CoV-2.
Not available
S-EPMC8715644 | biostudies-literature
TranscriptomicsTranscription profiling of 5 strains of rat: WKY, spontaneously hypertensive rat (SHR) and 3 reciprocal congenic strains (WconSA, SconSA and SISA)
5 strains of rat, WKY, spontaneously hypertensive rat (SHR) and 3 reciprocal congenic strains (WconSA, SconSA and SISA) were used to generate expression data across the genome using the Affymetrix rat genome chip set comprising the 230 A and 230 B chips. 5 animals from each strain were used. Express...
ORGANISM(S): Rattus norvegicus 
2007-04-16 | E-TABM-45 | biostudies-arrayexpress
TranscriptomicsChip-on-chip analysis of direct Nkx2.1 target genes in proliferating and differentiating epithelium in mouse lung development.
Nkx2.1 is a critical regulator of mammalian lung development. It is expressed in epithelial cells at the initiation of lung organogenesis, becoming progressively restricted during development to bronchiolar and alveolar type II epithelial cells. In humans, it is a common marker of carcinomas of lung...
ORGANISM(S): Mus musculus 
2011-11-01 | E-GEOD-23043 | biostudies-arrayexpress
Genomicsena-DATASET-CRUK-CI-16-05-2016-12:25:56:672-139 - samples
Targeted sequencing of 173 genes in 2433 primary breast tumours. Data includes 2433 tumour samples, 523 adjacent normal (breast) samples and 127 blood samples. Libraries were prepared with Illumina's Nextera custom enrichment kit targetting all the exons of the most frequently mutated breast cance...
EGAD00001002115 | EGA
GenomicsMETABRIC: Data from Pereira et al (2016), The somatic mutation profiles of 2433 breast cancers refine their genomic and transcriptomic landscapes. Nat Comms 7.
The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2433 primary breast tumours that have copy number aberration (CNA), gene expression, and long-term clinical follow-u...
EGAS00001001753 | EGA
TranscriptomicsEfficient derivation of purified lung and thyroid progenitors from embryonic stem cells
Two populations of Nkx2-1+ progenitors in the developing foregut endoderm give rise to the entire post-natal lung and thyroid epithelium, but little is known about these cells, as they are difficult to isolate in a pure form. We demonstrate here the purification and directed differentiation of primo...
ORGANISM(S): Mus musculus 
2012-04-04 | E-GEOD-35063 | biostudies-arrayexpress
TranscriptomicsClonal Genetic and Hematopoietic Heterogeneity among Human Induced Pluripotent Stem Cell lines
Induced pluripotent stem cells hold great promise for modeling human hematopoietic diseases. However, intrinsic variability in the capacities of different iPSC lines for hematopoietic development complicates comparative studies and is currently unexplained. We created and analyzed three separate iPS...
ORGANISM(S): Homo sapiens 
2013-07-26 | E-GEOD-49231 | biostudies-arrayexpress
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