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MetabolomicsProteomic and metabolomic profiling of acute and chronic stress events associated with military exercises.
By characterizing physiological changes that occur in warfighters during simulated combat, we can start to unravel the key biomolecular components that are linked to physical and cognitive performance. Viable field-based sensors for the warfighter must be rapid and noninvasive. In an effort to facil...
2023-12-05 | MTBLS5463 | MetaboLights
ProteomicsA Novel Approach to Interrogating the Effects of Chemical Warfare Agent Exposure Using Organ-on-a-Chip Technology and Multiomic Analysis
Organ-on-a-chip platforms are utilized in global bioanalytical and toxicological studies as a way to reduce materials and increase throughput as compared to in vivo based experiments. These platforms bridge the infrastructure and regulatory gaps between in vivo animal work and human systems, with mo...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037722 | Pride
Multiomics Organ on a chip Liver Lcms Organophosphate 
ProteomicsNormalization of Organ-on-a-Chip Samples for Mass Spectrometry Based Proteomics and Metabolomics via Dansylation-based Assay
Mass spectrometry based ‘omics pairs well with organ-on-a-chip-based investigations, which often have lim-ited cellular material for sampling. However, a common issue with these chip-based platforms is well-to-well or chip-to-chip variability in the proteome and metabolome due to factors such as pla...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD028927 | Pride
Liver Organ-on-a-chip Normalization 
ProteomicsChemical Probing Discovers New Insights into the Native Assembly State of a Bacterial Microcompartment
Microcompartments (BMCs) are widespread in bacteria and are used for a variety of metabolic purposes, including catabolism of host metabolites. A suite of proteins self-assembles into the shell and cargo layers of BMCs. However, the native assembly state of these large complexes remains to be elucid...
ORGANISM(S): Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
2022-08-19 | PXD029675 | Pride
Cross-linking Chemical modification Dynamic Interactome Bacterial microcompartment 
ProteomicsCaMKI dysregulation leads to autism-related phenotypes in precise synaptic connectivity, sleep, social behavior, and aging-dependent degeneration in Drosophila
Postmortem studies reveal increased density of synapses in brains of individuals with autism spectrum disorder (ASD. These observations have led to the hypothesis that defects in synaptic pruning may contribute to ASD pathology. Synaptic pruning, also called synaptic elimination or refinement, is a ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-10-06 | PXD061426 | Pride
Lc-msms Camk4 Label free Drosophila Autism Neuronal development 
ProteomicsDiribonuclease activity eliminates toxic diribonucleotide accumulation
RNA degradation is a central process in cells that is vital for transcriptional regulation. The degradation process is initiated by endoribonucleolytic fragmentation of long RNA polymers, followed by exoribonucleolytic cleavage to release mononucleotides from the fragment ends. In this process, the ...
ORGANISM(S): Pseudomonas aeruginosa PA14 Bacteria 
2024-09-16 | PXD052373 | Pride
Orn Rna degradation Yciv Lcms Bacteria Pseudomonas aeruginosa 
ProteomicsBacillus velezensis LoaP Promotes Antitermination of Antibiotic Synthesis Operons by Antagonizing NusA
The transcription factor NusG is essential for the bacterial transcription elongation complex (TEC). During elongation, NusG dynamically interacts with other proteins, affecting transcription-translation coupling, processivity, and termination. NusG is integral to antitermination complexes, where it...
ORGANISM(S): Bacillus velezensis FZB42 Bacteria 
2025-10-09 | PXD063323 | Pride
Transcription Loap Bacillus Lcms Antitermination Antibiotics 
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