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MetabolomicsOverexpression of Brassica napus COMT1 in Arabidopsis heightens UV-B-mediated resistance to Plutella xylostella herbivory

UV-B radiation regulates numerous morphogenic, biochemical and physiological responses in plants, and can stimulate some responses typically associated with other abiotic and biotic stimuli, including invertebrate herbivory. Removal of UV-B from the growing environment of various plant species ha...

2023-08-14 | MTBLS8236 | MetaboLights
UnknownA novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma.
Not available
S-EPMC8163735 | biostudies-literature
UnknownBCL-XL is an actionable target for treatment of malignant pleural mesothelioma.
Not available
S-EPMC7603509 | biostudies-literature
ProteomicsHydrogen Deuterium Exchange of MAF1 and RalGAP
A Toxoplasma gondii MAF1b - human RalGAPα1 complex highlights a potentially previously uncharacterized immunomodulatory role for MAF1b
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD034607 | Pride
Hdx Hdx-ms Ralgap Maf1 
UnknownTargeting IL-6 trans-signalling: past, present and future prospects.
Not available
S-EPMC10108826 | biostudies-literature
ProteomicsStudy of the TRAPP complexes by HDX-MS
Use of HDX-MS to study the allosteric and structural differences between the TRAPPII and TRAPPIII complex in the presence and absence of membrane and rab GTPases
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025928 | Pride
Trappii trappiii rab hdx-ms 
ProteomicsHDXMS of PI4KIIIa and Calcineurin
Using HDX-MS to reveal the binding sites of Calcineurin and PI4KIIIa
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025900 | Pride
Hdx-ms Pi4kiiia Calcineurin 
ProteomicsUsing HDX-MS to study Rab and Ral covalently bound to MRTX1257
Here we use HDX to study covalently modified Rab1a and RalA in both their apo states and bound to MRTX1257 to see how this compound affects the overall secondary structure of the proteins.
ORGANISM(S): Homo sapiens (Human) 
2025-03-10 | PXD041440 | Pride
Rab Hdx-ms Ral Hdx Gtpase 
UnknownUnlocking saponin biosynthesis in soapwort.
Not available
S-EPMC11782082 | biostudies-literature
ProteomicsDynamics of allosteric regulation of the phospholipase C-gamma isoform
we used hydrogen deuterium exchange masss spec (HDX-MS) to define the exchange kinetics of PLC-y1 as it interacts with the kinase domain of FGFR1, and liposomes containing PIP2, in order to understand how PLC-y isozymes operate at membranes. We show that the binding of FGFR1k to PLC-y1 increases deu...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-06-14 | PXD030492 | Pride
Hdxms Plc 
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