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ProteomicsAn Intrinsically Disordered Region of Ubp10 Governs its Specificity for Deubiquitinating H2A/H2B Dimers over Nucleosomes
Histone modifications perform a vast array of functions in regulating gene expression, DNA replication, and repair. Monoubiquitination of histone H2B at K123 in yeast (K120 in humans) is an intriguing modification because it is deposited cotranscriptionally, mediates the installation of several othe...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-16 | PXD051971 | Pride
Deubiqutinase Crosslinking mass spectrometry Ubiquitinated histone Ubp10 Single molecule fret Fact 
UnknownSurgical explantation of transcatheter aortic bioprostheses: Results and clinical implications.
Not available
S-EPMC7388726 | biostudies-literature
ProteomicsUsing HDX-MS to study Rab and Ral covalently bound to MRTX1257
Here we use HDX to study covalently modified Rab1a and RalA in both their apo states and bound to MRTX1257 to see how this compound affects the overall secondary structure of the proteins.
ORGANISM(S): Homo sapiens (Human) 
2025-03-10 | PXD041440 | Pride
Rab Hdx-ms Ral Hdx Gtpase 
UnknownGait speed is a preoperative indicator of postoperative events after elective proximal aortic surgery.
Not available
S-EPMC8722375 | biostudies-literature
UnknownPlacental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation.
Not available
S-EPMC9200719 | biostudies-literature
UnknownRisk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening.
Not available
S-EPMC4463475 | biostudies-literature
ProteomicsStructural Basis of Kinesin-1 Autoinhibition and Its Control of Microtubule-Based Motility
Kinesin-1 is the first identified microtubule-based motor protein that drives anterograde intracellular transport of diverse cargoes in eukaryotic cells. Defects in kinesin-1 activity have been implicated in various human neurological disorders and intracellular pathogens such as bacteria and viruse...
ORGANISM(S): Escherichia coli 
2026-06-03 | PXD073177 | Pride
Kinesin-1 Structure Kinesin Kif5b Plus-end directed Microtubule motor Cryo-em Motor protein 
ProteomicsProgress Toward Proteome-Wide Photo-Crosslinking to Enable Residue-Level Visualization of Protein Structure and Networks in vivo
Crosslinking mass spectrometry (XL-MS) is emerging as a method at the crossroads of structural and cellular biology, uniquely capable of identifying protein-protein interactions with residue-level resolution and on the proteome-wide scale. With the development of crosslinkers that can form linkages ...
ORGANISM(S): Escherichia coli 
2023-06-27 | PXD041148 | Pride
Diazirines Cleavable cross-linkers Proteomics Quinary interactions Nhs-carbamate. Photo-crosslinking Protein interaction networks 
UnknownModulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death.
Not available
S-EPMC6478651 | biostudies-literature
ProteomicsTargeting Ras-, Rho-, and Rab-Family GTPases via a Conserved Cryptic Pocket
The family of Ras-like GTPases consists of over 150 different members, regulated by an even larger number of guanine exchange factors (GEFs) and GTPase-activating proteins (GAPs) which comprise cellular switch networks that govern cell motility, growth, polarity, protein trafficking, and gene expres...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054414 | Pride
Gtpase 
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