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ProteomicsZAKb is a cellular compression sensor that mediates hypertrophic signaling in skeletal muscle
Mechanosensing is required for the senses of touch and hearing, and impacts on cellular processes such as cell differentiation, migration, invasion and tissue homeostasis. Mechanical inputs give rise to p38- and JNK-signaling, which mediates adaptive physiological responses in various tissues. In mu...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-31 | PXD028548 | Pride
Zak Phosphoproteomics Mouse. muscle 
ProteomicsCausal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses
The integration of multi-omic data sets can provide unique information about molecular processes in a cell. Despite the development of many tools to extract information from such data sets, there are limited strategies to systematically extract mechanistic hypotheses from them. We here present COSMO...
ORGANISM(S): Homo sapiens (Human) 
2021-02-02 | PXD018218 | Pride
Q exactive hf-x Human Kidney Phosphorylation 
ProteomicsMetaproteomic profiling of saliva in subjects with periodontitis, dental caries and orally healthy controls
The composition of the salivary microbiota has been reported to differentiate between patients with periodontitis, dental caries and orally healthy individuals. Thus, the purpose of the present investigation was to compare metaproteomic profiles of saliva in oral health and disease. Stimulated saliv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080763 | MassIVE
ProteomicsProteomics of NGF-TrkA signaling dynamics in neuroblastoma cells
We used quantitative mass spectrometry-based proteomics to unravel global nerve growth factor (NGF)-induced TrkA signaling dynamics at the interactome, phosphoproteome and proteome level. A tetracycline-inducible system for TrkA expression was generated in the human neuroblastoma cell line, SH-SY5Y....
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080834 | MassIVE
ProteomicsDissection of prognostic traits in colorectal cancer using multi-dimensional proteomics
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and the second leading cause of cancer death globally. The molecular mechanisms underlying CRC have been investigated using different omics technologies including genomics, proteomics, and metabolomics. Resulting molecular...
ORGANISM(S): Homo sapiens (Human) 
2025-03-26 | PXD044246 | Pride
Proteomics Colorectal cancer Phosphoproteomics 
ProteomicsHs_Hela_CellCycle_Phospho
HeLa S3 cells, SILAC labeled
ORGANISM(S): Homo Sapiens (human) 
2010-12-31 | PAe005252 | PeptideAtlas
TranscriptomicsDevelopment and blind clinical validation of a microRNA based predictor of response to treatment with R-CHOEP in DLBCL
microRNAs er are group of short noncoding RNAs that regulate gene expression at the posttranslational level. It has been shown that mirs are independent predictios of outcome in patients with diffuse large b cell lymphoma treated with r-chop. Outcome in patients with dlbcl lymphoma treated with r-ch...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-40239 | biostudies-arrayexpress
ProteomicsRegulation of the Golgi apparatus by p38 and JNK kinases during cellular stress responses
p38 and JNK are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful environment and/or an inflammatory state. Here, we utilized phospho-proteomics...
ORGANISM(S): Homo sapiens (Human) 
2021-09-13 | PXD028151 | Pride
P38 Jnk Golgi 
ProteomicsProtein accumulation post-LASIK surgery in granular corneal dystrophy type II patients involves altered proteolytic processing of transforming growth factor beta-induced protein (TGFBIp)
his study present the protein profile of diseased cornea from granular corneal dystrophy patients developing protein accumulation after LASIK surgery. Extracted ion chromatography (XIC) label free quantification was perform using Mascot Distiller software. In addition, 2D-PAGE followed by western bl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080219 | MassIVE
TranscriptomicsValidation of a laboratory assay for prediction of relapse in stage I non-small cell lung cancer (NSCLC) using miRNA profiling of formalin-fixed paraffin-embedded (FFPE) tissue specimens.
Technical validation of miRNA assay for prediction of relapse in NSCLC.
ORGANISM(S): Homo sapiens 
2011-10-28 | E-MTAB-618 | biostudies-arrayexpress
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