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ProteomicsStreptomyces coelicolor quantitative proteome and phosphoproteome analyses reveal proteins and phosphoproteins modulating differentiation and secondary metabolism
Investigation of proteome and phosphoproteome changes during Streptomyces coelictor life cycle using TMT tagging and calcium precipitation - titanium dioxide enrichment
ORGANISM(S): Streptomyces coelicolor 
2018-05-25 | PXD005558 | Pride
Streptomyces coelicolor Phosphoproteomics Tio2 
ProteomicsEffects of Canavanine on Human Glioblastoma Cells under Arginine Deprivation
We investigated the effect of canavanine (toxic Arg analogue) treatment on U251MG and U87MG cell lines using a variety of methods including proteomics. Since 3rd isotope of unmodified peptide cannot be resolved from canavanine containing peptide even at extremely high resolutions of 480K we incorpor...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD019044 | Pride
Canavanine Silac Human 
UnknownH3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.
Not available
S-EPMC4787770 | biostudies-literature
ProteomicsDynamic changes of histone H3 marks during Caenorhabditis elegans lifecycle revealed by middle-down proteomics
We applied a middle-down proteomics strategy for large scale protein analysis during in vivo development of Caenorhabditis elegans. We characterized post-translational modifications (PTMs) on histone H3 N-terminal tails at eight time points during the C. elegans lifecycle, including embryo, larval s...
ORGANISM(S): Caenorhabditis elegans 
2015-11-02 | PXD002525 | Pride
C. elegans Lifecycle Post-translational modifications Histones Middle-down proteomics 
ProteomicsPRMT5 methylome profiling uncovers a direct link to splicing regulation in human acute myeloid leukemia
Protein arginine methyltransferase 5 (PRMT5) belongs to the class II arginine methyltransferases and catalyzes monomethylation and symmetrical dimethylation of arginines on proteins. It has recently emerged as a promising cancer drug target, and two PRMT5 inhibitors are currently in clinical trials ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD013611 | Pride
Prmt5 Tmt Arginine methylation Ptm Human 
ProteomicsSystems level analysis of histone H3 post-translational modifications reveals features of PTM crosstalk in chromatin regulation
Chromatin structure and function is maintained by dynamic protein-protein and protein-nucleic acid interactions. Histones are a family of proteins that are abundant chromatin constituents and that carry numerous post-translational modifications (PTMs). Histone PTMs mediate a variety of biological ac...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-16 | PXD002560 | Pride
Post-translational modification  crosstalk  histone  mass spectrometry  proteomics 
ProteomicsComplex-dependent histone acetyltransferase activity of KAT8 determines its role in transcriptional regulation and cellular homeostasis [TMT11plex whole proteome analysis]
Histone acetylation is associated with open chromatin and transcriptionally active genes. Specifically, acetylation of lysine 16 on histone H4 (H4K16ac) has been shown to prevent the assembly of nucleosomal arrays in vitro. This modification is catalyzed by the MYST-family histone acetyltransferase ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD023865 | Pride
Nsl Msl Histone Kat8 
ProteomicsComplex-dependent histone acetyltransferase activity of KAT8 determines its role in transcriptional regulation and cellular homeostasis [histone dataset]
Histone acetylation is associated with open chromatin and transcriptionally active genes. Specifically, acetylation of lysine 16 on histone H4 (H4K16ac) has been shown to prevent the assembly of nucleosomal arrays in vitro. This modification is catalyzed by the MYST-family histone acetyltransferase ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD021943 | Pride
Nsl Msl Histone Kat8 
ProteomicsComplex-dependent histone acetyltransferase activity of KAT8 determines its role in transcriptional regulation and cellular homeostasis [AP-MS]
Histone acetylation is associated with open chromatin and transcriptionally active genes. Specifically, acetylation of lysine 16 on histone H4 (H4K16ac) has been shown to prevent the assembly of nucleosomal arrays in vitro. This modification is catalyzed by the MYST-family histone acetyltransferase ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD022267 | Pride
Nsl Msl Histone Kat8 
UnknownQuantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36.
Not available
S-EPMC2871418 | biostudies-literature
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