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UnknownGentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
Not available
S-EPMC3567692 | biostudies-literature
ProteomicsZirconium(IV)-IMAC for phosphopeptide enrichment in phosphoproteomics
IMAC and MOAC magnetic microsphere materials were tested with ug amounts of protein extracts from HepG2/C3A cells. We compared Zirconium (IV) IMAC (Zr-IMAC) magnetic microspheres to commonly used Titanium (IV) IMAC (Ti-IMAC) and TiO2 magnetic microspheres for phosphopeptide enrichment from simple an...
ORGANISM(S): Homo sapiens (Human) 
2020-11-26 | PXD018273 | Pride
Affinity enrichment Moac Imac Mass spectrometry Protein phosphorylation Functional proteomics Cell signalling Magnetic particles 
ProteomicsEffects of Canavanine on Human Glioblastoma Cells under Arginine Deprivation
We investigated the effect of canavanine (toxic Arg analogue) treatment on U251MG and U87MG cell lines using a variety of methods including proteomics. Since 3rd isotope of unmodified peptide cannot be resolved from canavanine containing peptide even at extremely high resolutions of 480K we incorpor...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD019044 | Pride
Canavanine Silac Human 
OtherGlobal mass spectrometry and transcriptomics array based drug profiling provides novel insight into glucosamine induced ER stress.
Data from ProteomeXchange, PXD ID: PXD000380. Experiment: Treatment, file: MS12236QE_rune_henrik_Treatment_c.mzml. Published as part of Mol Cell Proteomics. 2014 Aug 15 . From the Abstract: {{i}} We investigated the molecular effects of glucosamine supplements, a popular and safe alternative to non...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310003280 | GPMDB
Resource Reanalysis 
TranscriptomicsTranscription profiling of composite bone marrow from healthy humans to investigate age related gene expression changes
Human bone marrow is a complex, diversified and well-organized hematopoietic network changing composition with age. The purpose of this study was to analyze variations in relative precursor B cell abundance in bone marrow with age by means of global gene expression profiling. RNA was isolated from c...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-11504 | biostudies-arrayexpress
UnknownAir pollution from traffic and cancer incidence: a Danish cohort study.
Not available
S-EPMC3157417 | biostudies-literature
TranscriptomicsRNA-seq of Glioma Neural Stem (GNS) cell line G144 after MEK inhibition in wild type (WT) and CIC (Capicua) depleted cells.
We identified genome-wide binding patterns of CIC in several different cell types and find that CIC target genes are enriched for MAPK effector genes involved in cell cycle regulation and proliferation. CIC binding to its target genes is abolished by high MAPK activity, which leads to hyperacetylati...
ORGANISM(S): Homo sapiens 
2018-05-31 | E-MTAB-6681 | biostudies-arrayexpress
GenomicsChIP-seq of CIC (Capicua) and histone marks (H3K9ac, H3K27ac and H3K4me1) in glioma neural stem cells (GNS) G144, human foetal neural stem cells (hNSC) and mouse embryonic stem cells (mESC),
We identified genome-wide binding patterns of CIC in several different cell types and find that CIC target genes are enriched for MAPK effector genes involved in cell cycle regulation and proliferation. CIC binding to its target genes is abolished by high MAPK activity, which leads to hyperacetylati...
ORGANISM(S): Homo sapiens 
2018-05-31 | E-MTAB-6682 | biostudies-arrayexpress
UnknownModeling Metastatic Colonization in a Decellularized Organ Scaffold-Based Perfusion Bioreactor.
Not available
S-EPMC11469127 | biostudies-literature
UnknownTumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals.
Not available
S-EPMC4650424 | biostudies-literature
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