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ProteomicsProteomic analysis of human PARK2 knockout iPSC-derived neurons
Mitochondrial dysfunction plays a major role in the pathogenesis of sporadic Parkinson’s disease (PD) and familial PD caused by mutations in the PARK2 gene. The protein, parkin, is vital for mitochondrial function, but the lack of key PD phenotypes in PARK2 knockout (KO) rodent models has hindered i...
ORGANISM(S): Homo sapiens (Human) 
2019-09-03 | PXD007871 | Pride
Lc-msms Qexactive-hf Parkinson's disease Human ips cells 
ProteomicsProteomic analysis of GBA iPSC-dopamine neurons
Heterozygous mutations in the glucocerebrosidase gene (GBA) are the strongest common genetic risk factors for Parkinson’s disease (PD) present in around 5-10% of PD patients, resulting in lower age of onset and exacerbating disease progression, including an increased risk of dementia. However, the e...
ORGANISM(S): Homo sapiens (Human) 
2023-03-04 | PXD026691 | Pride
Neuritogenesis/parkinson’s/proteomics/stem cells/glucocerebrosidase/post-translational modification 
UnknownPristane-induced arthritis loci interact with the Slc11a1 gene to determine susceptibility in mice selected for high inflammation.
Not available
S-EPMC3914970 | biostudies-literature
ProteomicsProteomic characterisation of lysosomal and mitochondrial perturbations in human iPSC-derived neurons with PARK2 mutation
Mitochondrial dysfunction plays a major role in the pathogenesis of sporadic Parkinson’s disease (PD) and familial PD caused by mutations in the PARK2 gene. The protein, parkin, is vital for mitochondrial function, but the lack of key PD phenotypes in PARK2 knockout (KO) rodent models has hindered i...
ORGANISM(S): Homo sapiens (Human) 
2019-07-26 | PXD008894 | Pride
Human Lc-msms Ipsc Tmt Park2 Mitochondria 
ProteomicsQuantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users
We analyzed non-atherosclerotic repair arteries gathered at coronary by-pass operations from 30 patients with type 2 diabetes, as well as from 30 age- and gender-matched non-diabetic individuals. Quantitative proteome analysis was done by iTRAQ-labelling and LC-MS/MS analysis on individual arterial ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080848 | MassIVE
ProteomicsCharacterization of signaling pathways associated with pancreatic β-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice
Obesity-linked type 2 diabetes (T2D) is a major health problem of global epidemic proportions. The onset of T2D is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to o...
ORGANISM(S): Mus Musculus 
2020-05-18 | PXD016392 | panorama
UnknownComparison of cable bacteria genera reveals details of their conduction machinery
Not available
S-SCDT-10_1038-S44319-025-00387-8 | biostudies-other
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