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ProteomicsIntegrating metabolic and evolutionary engineering for enhanced propionic acid production under cross stress: a multi-omics perspective
We performed a combination of metabolic engineering (deletion of ldh and poxB and overexpression of mmc) with evolutionary engineering (selection under oxygen stress, acid stress and osmotic stress) in Propionibacterium acidipropionici. The results indicated that the mutants had superior physiologic...
ORGANISM(S): Acidipropionibacterium acidipropionici 
2020-04-27 | PXD016616 | Pride
Omics analysis Cross stress Metabolic and evolutionary engineering Propionibacterium acidipropionici Propionic acid 
MetabolomicsMetabolomic analysis of alfalfa (Medicago sativa L.) root-symbiotic rhizobia responses under alkali stress
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relat...
2018-07-27 | MTBLS481 | MetaboLights
ProteomicsMiddle-Down Characterization of the Cell Cycle Dependence of Histone H4 PTMs and Proteoforms
In the present study, a middle-down approach is employed for the identification, characterization, and quantitation of the PTMs and proteoforms of histone H4 in two breast cancer cell lines. Our experimental strategy not only preserves the combinatorial attributes of existing PTMs, but also enhances...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD008296 | Pride
Hilic Ft-icr Ptm Mass spectrometry Etd 
TranscriptomicsmicroRNA expression in Tim-3 knockdown RAW264.7 cell
RAW264.7 cell was stably transfected with Tim-3 siRNA(SI) or negative control(NC) and were analyzed for microRNA expression Differerently expressed microRNA in Tim-3 knockdown RAW264.7 cells were summarized and were used for further analysis RAW264.7 cells stably transfected with Tim-3 siRNA(SI) o...
ORGANISM(S): Mus musculus 
2016-01-14 | E-GEOD-76839 | biostudies-arrayexpress
ProteomicsH2B variants expression during iAs-mediated EMT
This work details the first global mass spectrometric analysis of histone H2B variants as cells undergo arsenic-mediated epithelial to mesenchymal transition.
ORGANISM(S): Homo sapiens (Human) 
2016-05-17 | PXD003503 | Pride
Ion cyclotron resonance Proteomics Toxin Epigenetics Mass spectrometry Proteoform Transformation Top-down Fourier transform Inorganic arsenic Histone variants 
ProteomicsDetect the shared protein components between spider dragline silk and silkworm cocoon by Label free quantitative proteomics
The spider major ampullate gland and silkworm silk gland have similar morphological structure and function, so we explored whether there are some common protein components on silks, with three biological replicates for each sample. Dragline silk samples from mature female Trichonephila clavata spide...
ORGANISM(S): Bombyx Mori Trichonephila 
2022-12-09 | PXD038734 |
MetabolomicsGNPS - Serum integrative omics reveals the landscape of human diabetic kidney disease
Diabetic kidney disease (DKD) is the most common microvascular complication of type 2 diabetes mellitus (2-DM). Currently, urine and kidney biopsy specimens are the major clinical resources for DKD diagnosis. The diagnostic values of blood in monitoring the onset and progression of DKD have not been...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-22 | MSV000087487 | GNPS
ProteomicsProteins that interaction with SCARB2 in HCCLM3 cells and analysis of acetylation site of MYC in SCARB2-overexpressing HCCLM3 cells
Quantitative mass spectrometry (MS)-based proteomics to assess acetylation modification of MYC in HCCLM3 cells with SCARB2 overexpression and analysis of SCARB2 immunoprecipitates in HCCLM3 cells.
ORGANISM(S): Homo Sapiens 
2023-08-12 | PXD044544 |
ProteomicsSerum integrative omics reveals the landscape of human diabetic kidney disease
Diabetic kidney disease (DKD) is the most common microvascular complication of type 2 diabetes mellitus (2-DM). Currently, urine and kidney biopsy specimens are the major clinical resources for DKD diagnosis. The diagnostic values of blood in monitoring the onset and progression of DKD have not been...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-22 | MSV000087487 | MassIVE
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
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