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ProteomicsGlycoproteomics revealed novel N-glycosylation biomarkers for early diagnosis of lung adenocarcinoma cancers
Circulating biomarkers play important roles in diagnosis of malignant tumors. N-glycosylation is an important post-translation patter and obviously affect biological behaviors of malignant tumor cells. However, the role of N-glycosylation sites in early diagnosis of tumors still remains further inve...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036198 | Pride
Lung adenocarcinoma  early diagnosis  circulating biomarkers  n-glycosylation  machine learning. 
TranscriptomicsMicroarray analysis of cross-talks between Jasmonate acid and ethylene signaling in Arabidopsis seedlings
Jasmonate and ethylene are two important plant hormones contributing plant resistance to biotic stresses synergistically. Our experimental results showed that two ethylene activated transcription factors (EIN3/EIL1) integrated both jasmonate and ethylene signaling in multiple developmental and defen...
ORGANISM(S): Arabidopsis 
2010-05-28 | E-GEOD-21762 | biostudies-arrayexpress
ProteomicsProteomic analysis of PDCoV-infected HIEC-6 cells
Data-independent acquisition (DIA) is a new type of mass spectrometry data acquisition developed in recent years. The entire scanning range of mass spectrometry can be divided into several windows based on the mass-to-charge ratio (m/z), and then all the parent ions in each window are fragmented and...
ORGANISM(S): Homo Sapiens 
2024-02-20 | PXD049713 |
ProteomicsIonizable polymeric micelles (IPMs) for efficient siRNA delivery
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance. We design three ionizable oligo-mers (IOs) that, with PLA-PEG, form Ionizable Polymeric Micelles (IPMs), a potential siRNA delivery system, which can achie...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-21 | PXD057444 | Pride
Hsp47 Protein corona Hmgb1 Hepatic fibrosis Fibroblast activation protein inhibitor (fapi) Nucleic acid delivery Ionizable polymeric micelles (ipms) Hepatic stellate cells 
UnknownApatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia.
Not available
S-EPMC5831852 | biostudies-literature
ProteomicsDeacetylation Induced Nuclear Condensation of HP1γ Promotes Multiple Myeloma Drug Resistance
Functional crosstalk between histone modifications and chromatin remodeling has emerged as a key regulatory mode of transcriptional control during drug resistance, but the underlying mechanisms are not fully understood. Here we demonstrate that different proteins and their acetylation modification r...
ORGANISM(S): Homo Sapiens 
2023-02-20 | PXD040298 |
GenomicsPi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [ChIPseq]
Background—YAP, the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEAD sequence specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the d...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-57717 | biostudies-arrayexpress
ProteomicsMolecular Phenomics of the Gut Ecosystem in COVID-19 Patients
Stool metaproteomics of COVID-19 patients and healthy subjects to discover host and microbial protein alterations of gut ecosystem.
ORGANISM(S): Homo Sapiens 
2020-12-14 | PXD023099 |
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