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ProteomicsThe inflammation repressor TNIP1 is degraded by selective autophagy in a LIR-dependent manner upon TLR3 activation
In the project « The inflammation repressor TNIP1 is degraded by selective autophagy in a LIR-dependent manner upon TLR3 activation » Jianwen Zhou, Nikoline Lander Rasmussen, Vyacheslav Akimov, Blagoy Blagoev, Trond Lamark, Terje Johansen and Jörn Dengjel performed MS-based proteomics to study the f...
ORGANISM(S): Homo sapiens (Human) 
2022-08-07 | PXD027163 | Pride
Lc-msms Inflammation Silac Human 
ProteomicsCALCOCO1 acts with VAMP-Associated Proteins to mediate ER-phagy
To explore the interaction partners of CALCOCO1, we immunoprecipitated EGFP-CALCOCO1 from HEK 293 cells’ lysate and identified the bound proteins by mass spectrometry. The identified proteins were then filtered against GFP control.
ORGANISM(S): Homo sapiens (Human) 
2020-06-02 | PXD018894 | Pride
Golgi Vapb Vapa Er-phagy Ffat motif Calcoco1 Autophagy 
ProteomicsNIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
We found that LC3B is phosphorylated in vitro by STK3, STK4, NEK9, and PKCζ. To identify phosphorylation sites following in vitro phosphorylation, GST-LC3B was overexpressed in E. coli, purified using glutathione-Sepharose 4 Fast Flow beads and incubated in kinase assays with recombinant kinases or ...
ORGANISM(S): Homo sapiens (Human) 
2020-01-23 | PXD016681 | Pride
Microtubule-associated lc3b protein Autophagy In vitro phosphorylation 
ProteomicsAtg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
Stress granule formation is a part of cellular homeostatic responses, with prototypical inducers being viral infections, heat shock and oxidative damage. Here we show that lysosomal damage is a previously unappreciated robust inducer of stress granule formation interlinked with mTOR inactivation dur...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088152 | MassIVE
ProteomicsMembrane atg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosome-damaging agents including SARS-CoV-2ORF3a, Mycobacteri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-09 | MSV000089622 | MassIVE
ProteomicsATG9A is a component of the ESCRT system and governs plasma membrane repair
ATG9 is often described as the sole transmembrane protein among the core autophagy factors. The mammalian ATG9A is notorious for trafficking through numerous cellular compartments including the plasma membrane. The reasons for ATG9As wide intracellular distribution and its role at the PM are not ful...
ORGANISM(S): Homo 
2019-10-30 | MSV000084519 | MassIVE
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