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MetabolomicsLimitations to Starch Utilization in Barramundi (Lates calcarifer) as Revealed by NMR-Based Metabolomics
Practical diets for commercial barramundi production rarely contain greater than 10% starch, used mainly as a binding agent during extrusion. Alternative ingredients such as digestible starch have shown some capacity to spare dietary protein catabolism to generate glucose. In the present study, a ca...
2020-07-30 | MTBLS1103 | MetaboLights
ProteomicsAntisense affinity selection of the lncRNA NTRAS in HeLa lysate
Biochemical characterization of the hypoxia-induced long non coding RNA NTRAS. NTRAS was found to regulate cell cycle progression, in vitro sprouting angiogenesis, and the paracellular permeability in human umbilical vein endothelial cells (HUVECs). Using desthiobiotinylated 2’O-Me-RNA probes, we pu...
ORGANISM(S): Homo sapiens (Human) 
2022-04-25 | PXD030620 | Pride
Rna-protein-interaction Antisense affinity selection Lncrna 
ProteomicsCharacterisation of the protein cargo of murine plasma microparticles released during experimental cerebral malaria
Cerebral malaria (CM) is a severe complication of a Plasmodium falciparum infection and is still responsible for a high number of deaths and long term disabilities in children in sub-Saharan Africa. The pathogenesis of this syndrome remains incompletely understood but a number of mechanisms and effe...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-13 | PXD003772 | Pride
Qexactive orbitrap Protein cargo Tandem mass tag (tmt) Microparticles Experimental cerebral malaria 
UnknownCross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages.
Not available
S-EPMC9848280 | biostudies-literature
UnknownProphylactic Use of Cardiac Medications and Survival in Duchenne Muscular Dystrophy.
Not available
S-EPMC11887528 | biostudies-literature
ProteomicsTumour mtDNA mutations drive aerobic glycolysis to enhance checkpoint blockade (part 2)
Mitochondrial DNA (mtDNA) encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutations in the cancer genome, with truncating mutations in complex I genes being over-represented1 . While mtDNA mutations have been associ...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-08 | PXD044987 | Pride
Melanoma Cancer Complex i Mitochondrial dna 
MetabolomicsInsights into Metabolic Changes Caused by the Trichoderma virens-Maize Root Interaction
The interactions of crops with root-colonizing endophytic microorganisms are highly relevant to agriculture, because endophytes can modify plant resistance to pests and increase crop yields. We investigated the interactions between the host plant Zea mays and the endophytic fungus Trichode...
2021-07-08 | MTBLS1964 | MetaboLights
ProteomicsIntegrative functional proteomics identifies PARP1 protein complex differences and PARP inhibitor-mediated DDR and AKT-mTOR signaling in ovarian carcinoma: Phosphoproteomics
BRCA1/2-deficient ovarian carcinoma (OC) has been shown to be particularly sensitive to PARP inhibitors (PARPis) and BRCA1/2 mutation status is currently used as a predictive biomarker for PARPi therapy. Despite eliciting major clinical benefit for the majority of patients, a significant proportion ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-21 | PXD029432 | Pride
Ovarian cancer Phosphoproteomics Parp1 Brca 
UnknownEvaluating DNA Methylation in Random Fine Needle Aspirates from the Breast to Inform Cancer Risk.
Not available
S-EPMC11401740 | biostudies-literature
ProteomicsFAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer
Cancer-associated fibroblasts (CAFs), although considered as the most abundant pancreatic ductal adenocarcinoma (PDAC) stromal cells playing a critical role in tumor progression and chemoresistance, are not yet directly druggable. Here we report that focal adhesion kinase (FAK) activity (evaluated b...
ORGANISM(S): Homo sapiens (Human) 
2020-08-19 | PXD018899 | Pride
Fak Cancer-associated fibroblasts Pancreatic cancer Extracellular matrix 
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