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UnknownGlobal Expansion of Jeffrey's Insights: Jeffrey Modell Foundation's Genetic Sequencing Program for Primary Immunodeficiency.
Not available
S-EPMC9226364 | biostudies-literature
UnknownJeffrey's insights: Jeffrey Modell Foundation's global genetic sequencing pilot program to identify specific primary immunodeficiency defects to optimize disease management and treatment.
Not available
S-EPMC7335369 | biostudies-literature
ProteomicsGlobal post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling
Viruses must effectively remodel host cellular pathways to replicate and evade immune defenses, and they must do so with limited genomic coding capacity. Targeting post-translational modification (PTM) pathways provides a mechanism by which viruses can broadly and rapidly transform a hostile host en...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD032085 | Pride
Hiv-1 Proteomics Vif B56 Ubiquitination Vpr Pp2a Phosphorylation Histone h1 Systems biology 
ProteomicsQuantitative tissue proteomics reveals increased pathogenesis associated with infection with the SARS-CoV-2 Delta variant that is independent of viral infectivity in Syrian golden hamsters
Background: Since its emergence in 2020, circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been dominated by waves of genetically distinct variants with varying pathogenicity. Understanding the molecular mechanisms underlying SARS-CoV-2 pathogenesis, and the host and viral...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2026-01-26 | PXD054808 | Pride
Sars-cov-2 Proteomics Hamster Phosphoproteomics Pathogenesis 
ProteomicsImmunological landscape of human lymphoid explants during measles virus infection
In humans, lymph nodes are the primary site of measles virus (MeV) replication. To understand the immunological events that occur at this site, we infected human lymphoid tissue explants using a pathogenic strain of MeV that expresses GFP. We found that MeV infected between 5-15% of cells across don...
ORGANISM(S): Homo sapiens (Human) 
2024-09-10 | PXD054861 | Pride
Lymph node Measles virus 
ProteomicsImmunization of mice with virus-like vesicles of Kaposi sarcoma-associated herpesvirus reveals a role of ORF4 in complement-mediated neutralization
The development of a prophylactic vaccine for Kaposi sarcoma-associated Herpesvirus (KSHV) would prevent consequences from infection including disorders such as Kaposi sarcoma and primary effusion lymphoma. Here, we study the immunogenicity of noninfectious virus-like vesicles (VLVs) of KSHV as a po...
ORGANISM(S): Homo sapiens (Human) Human gammaherpesvirus 8 
2023-02-01 | PXD035478 | Pride
Kshv herpesvirus 
ProteomicsUnveiling Alternate Pathways for SARS-CoV-2 Infection via Extracellular Vesicle-Mediated Transfer of ACE2 and TMPRSS2
The COVID-19 pandemic, caused by SARS-CoV-2, has underscored the urgency of understanding viral entry mechanisms to develop effective therapeutic strategies. SARS-CoV-2 primarily exploits angiotensin-converting enzyme 2 (ACE2) as its entry receptor and relies on the serine protease TMPRSS2 to prime ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-11 | PXD075507 | Pride
Sars-cov-2 Tmprss2 Ace2 
ProteomicsUnveiling Alternate Pathways for SARS-CoV-2 Infection via Extracellular Vesicle-Mediated Transfer of ACE2 and TMPRSS2
The COVID-19 pandemic, caused by SARS-CoV-2, has underscored the urgency of understanding viral entry mechanisms to develop effective therapeutic strategies. SARS-CoV-2 primarily exploits angiotensin-converting enzyme 2 (ACE2) as its entry receptor and relies on the serine protease TMPRSS2 to prime ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-25 | PXD075505 | Pride
Sars-cov-2 Tmprss2 Ace2 
ProteomicsThe EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8⁺ T-cell revitalization
Persistent HIV reservoirs in CD4⁺ T-cells impede efforts to cure HIV infection. We identified overexpression of enhancer of zeste homolog 2 (EZH2) in HIV-infected CD4⁺ T-cells that survive cytotoxic T lymphocyte (CTL) exposure, suggesting a mechanism of CTL resistance. Inhibition of EZH2 with the FD...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD061146 | Pride
Hiv Cd8 t cells Ezh2 Tazemetostat 
ProteomicsGeneration of a high yield vaccine backbone for influenza B virus in embryonated chicken eggs
Influenza B virus (IBV) strains are one of the components of seasonal influenza vaccines in both trivalent and quadrivalent formulations. The vast majority of these vaccines are produced in embryonated chickens' eggs. While optimized backbones for vaccine production in eggs exist and are in use for ...
ORGANISM(S): Influenza A virus (A/Florida/2e/2006(H3N2)) Influenza B virus (B/Hawaii/10/2001) Influenza C virus (C/Great Lakes/1167/1954) Influenza C virus 
2023-03-10 | PXD036269 | Pride
Backbone Vaccine Influenza b virus High yield 
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