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MetabolomicsA Python-based pipeline for preprocessing LC-MS data for untargeted metabolomics workflows
Preprocessing data in a reproducible and robust way is one of the current challenges in untargeted metabolomics workflows. Data curation in liquid chromatography-mass spectrometry (LC-MS) involves the removal of unwanted features (retention time; m/z pairs) to retain only high-quality data for subse...
2020-11-21 | MTBLS1919 | MetaboLights
ProteomicsLabeling preferences of diazirines with protein biomolecules
Diazirines are widely used in photoaffinity labeling (PAL) to trap non-covalent interactions with biomolecules. However, design and interpretation of PAL experiments is challenging without a molecular understanding of the reactivity of diazirines with protein biomolecules. Here, we report a system...
ORGANISM(S): Homo sapiens (Human) 
2022-07-20 | PXD025140 | Pride
Sknsh cells Diazirine Photoaffinity labeling Proteomics Binding sites 
UnknownHyaluronan provokes inflammation but suppresses phagocytotic function in macrophages.
Not available
S-EPMC11717599 | biostudies-literature
Proteomics4-deoxy-4-fluoro-GalNAz (4FGalNAz) is a metabolic chemical reporter of O-GlcNAc modifications, highlighting the notable substrate flexibility of O-GlcNAc transferase
Bioorthogonal chemistries have revolutionized many fields. For example, metabolic chemical reporters (MCRs) of glycosylation are analogs of monosaccharides that contain bioorthogonal functionality, like azides or alkynes. MCRs are metabolically incorporated into glycoproteins by living systems, and ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027333 | Pride
O-glcnac  tmt 
UnknownInvestigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model.
Not available
S-EPMC10327714 | biostudies-literature
MetabolomicsGNPS - New Human Plasma Reference Materials - Aristizabal-Henao et al., 2020
Nontargeted lipidomics of novel human plasma reference materials
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-27 | MSV000085476 | GNPS
UnknownAssociations between nonalcoholic fatty liver disease and subclinical atherosclerosis in middle-aged adults: the Coronary Artery Risk Development in Young Adults Study.
Not available
S-EPMC4124046 | biostudies-literature
ProteomicsIsolation of Arabidopsis EDS1 complexes from leaves with activated TNL RPS4/RRS1 signaling
Nod-like receptors (NLRs) belong to AAA+ ATPases and act as ATP-dependent molecular switches, which detect activity of pathogens. Function of a large class of plant NLRs with Toll-like domain (TNL) is fully dependent on a class of EDS1-like proteins specific to seed plants. EDS1 (Enhanced Disease Su...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-04-06 | PXD025202 | Pride
Arabidopsis Tnl Helper nlr Sag101 Pad4 Immunity 
ProteomicsComparative analysis of PAD4 and SAG101 interactors upon activation of NLR immunity in Arabidopsis thaliana
Intracellular NLR receptors with a central nucleotide-binding domain allow plants to detect specific pathogen-secreted proteins and initiate immune signaling. A family of conserved Enhanced disease susceptibility 1 proteins with a lipase-like and the EP domain transduces the signal from activated NL...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-04-06 | PXD021301 | Pride
Arabidopsis Tnl Helper nlr Sag101 Pad4 Immunity 
UnknownBreast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.
Not available
S-EPMC3387216 | biostudies-literature
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