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ProteomicsCell-specific information processing in segregating populations of Eph receptor-ephrin-expressing cells
Cell-specific information processing in segregating populations of Eph receptor-ephrin-expressing cells
ORGANISM(S): Homo sapiens (Human) 
2009-12-11 | PRD000814 | Pride
ProteomicsHeterocellular OSM-OSMR signalling drives pancreatic tumour growth and metastasis through functional fibroblast reprogramming
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy characterised by a pathologicalfibroinflammatorymicroenvironment. Dichotomous tumour-promoting and -restrictive roles have been ascribed to the tumour microenvironment, however thedisparate effect of individual stromal subsets remains inc...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-29 | PXD022484 | Pride
Phosphoproteomics Pda Mouse 
ProteomicsA microenvironment-inspired synthetic 3D model for pancreatic ductal adenocarcinoma organoids - PDA Matrisome
LFQ analysis of matrisome fractions enriched from 12 murine PDA or PanIN samples (samples 1 - 12) and a normal pancreas pool (samples 13) pooled from 10 pancreata of C57-Bl6 animals. Three independent enrichments have been conducted for each sample with each having had four injections.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-29 | PXD022767 | Pride
Ecm Pdac Cancer Syntheticmatrix 
ProteomicsA microenvironment-inspired synthetic 3D model for pancreatic ductal adenocarcinoma organoids - Pancreas matrisome atlas
LC-MS/MS based analysis of the normal pancreas matrisome from 10 C57-Black6 animals. Matrisome abundance was quantified using a label-free quantification approach.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-29 | PXD022555 | Pride
Ecm Pdac Organoids Syntheticmatrix Pancreas 
ProteomicsCell-Specific Labeling Enzymes For Analysis of Cell-Cell Communication in Continuous Co-Culture, Part 2 / 2
We report the orthologous screening, engineering and optimization of amino acid conversion enzymes for cell-specific proteomic labeling.
ORGANISM(S): Mus musculus (Mouse) 
2014-05-29 | PXD000871 | Pride
Ctap 
ProteomicsCell-specific analysis of tumour-endothelial contact-intiated signalling
Tumour cell extravasation is a key event for metastatic colonisation1. However, little is known about the signalling pathways that govern tumour cell adhesion to the endothelium and subsequent transmigration through the blood vessel wall. Here, we combine Stable Isotope Labelling by Amino acids in C...
ORGANISM(S): Homo sapiens (Human) 
2016-02-12 | PXD001558 | Pride
Orbitrap velos Phospho Contact-initiated signalling Silac Transendothelial migration Mda-mb-231 Huvec 
ProteomicsCell-specific analysis of tumour-endothelial contact-intiated signalling - PROTEOMICS
Metastasizing tumor cells exit the vascular system through dynamic interactions with endothelial cells that line the internal surface of vessels. While extravasation is a key event within the metastatic cascade, the signals regulating tumor cell adhesion to the endothelium and their subsequent trans...
ORGANISM(S): Homo sapiens (Human) 
2016-02-12 | PXD003048 | Pride
Epha2 Mda-mb-231-lm2 "contact-initiated signaling" Huvec 
ProteomicsCell-Specific Labeling Enzymes For Analysis of Cell-Cell Communication in Continuous Co-Culture, Part 1 / 2
We report the orthologous screening, engineering and optimization of amino acid conversion enzymes for cell-specific proteomic labeling.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2014-05-29 | PXD000870 | Pride
Ctap 
ProteomicsCell-Specific Labeling Enzymes For Analysis of Cell-Cell Communication in Continuous Co-Culture
We report the orthologous screening, engineering and optimization of amino acid conversion enzymes for cell-specific proteomic labeling.
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD000739 | Pride
Ctap lyr ddc 
ProteomicsOncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation
Oncogenic mutations in tumor cells regulate signaling both within tumor cells and heterotypic stromal cells. However, whether oncogenes regulate tumor cell signaling via stromal cells is poorly understood. Here we show that oncogenic KRAS (KRAS-G12D) uniquely regulates tumor cell signaling via strom...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-19 | PXD003223 | Pride
Kras pda phosphoproteomics tmt ape silac ctap 
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