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UnknownStructural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome.
Not available
S-EPMC12528685 | biostudies-literature
ProteomicsCross-link MS analysis of human 26S proteasome in complex with RPN13:UCHL5 (with substrate).
This project investigates how the human 26S proteasome recognizes and processes proteins tagged with K11/K48-branched ubiquitin chains, which signal for rapid degradation during cell cycle progression and proteotoxic stress. Using cryo-electron microscopy (cryo-EM), the study uncovers a novel K11-li...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD064932 | Pride
K11/k48 ubiquitin Rpn13 Proteasome Uchl5 26s Branched ubiquitin 
UnknownBranching via K11 and K48 Bestows Ubiquitin Chains with a Unique Interdomain Interface and Enhanced Affinity for Proteasomal Subunit Rpn1.
Not available
S-EPMC6996796 | biostudies-literature
ProteomicsCross-link MS analysis of human 26S proteasome in complex with RPN13:UCHL5 (without substrate).
This project investigates how the human 26S proteasome recognizes and processes proteins tagged with K11/K48-branched ubiquitin chains, which signal for rapid degradation during cell cycle progression and proteotoxic stress. Using cryo-electron microscopy (cryo-EM), the study uncovers a novel K11-li...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD064931 | Pride
Rpn13 Proteasome Uchl5 26s 
ProteomicsMARCH1 ubiquitination of MHC II generates a branched K63/K11 ubiquitin chain.
Major histocompatibility class II (MHC II) is critical for adaptive immunity. MHC II intracellular trafficking and degradation is regulated by ubiquitination, with poly-ubiquitination (Ub) of MHC II directing it away from the plasma membrane. The MHC II poly-Ub chain that dictates the fate and funct...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-01 | PXD063057 | Pride
Ubiquitin Mhcii Ub-code Aqua peptides 
ProteomicsAlterations in proteome and proteostasis networks during replicative senescence
The accumulation of senescent cells constitutes a pivotal hallmark of tissue ageing, contributing to disruption of tissue homeostasis and thus, to the development of several aging-related diseases. Despite this, our knowledge about the molecular, spatial and temporal changes that drive aging on a ce...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD069085 | Pride
Ubiquitin profilling Replicative senescence 
UnknownProteomics Links Ubiquitin Chain Topology Change to Transcription Factor Activation.
Not available
S-EPMC7751889 | biostudies-literature
UnknownAssembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.
Not available
S-EPMC5669814 | biostudies-literature
UnknownQuantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation.
Not available
S-EPMC2668214 | biostudies-literature
ProteomicsThe E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis
Mechanistic studies of how protein ubiquitylation regulates the cell cycle, in particular during mitosis, have provided unique insights which have contributed to the emergence of the ‘Ubiquitin code’. In contrast to RING E3 ubiquitin ligases such as the APC/c ligase complex, the contribution of othe...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD035503 | Pride
Ubiquitin E3 ubiquitin ligase Cell proliferation Trabid Hectd1 Cell cycle 
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