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ProteomicsProMetheus: a database of hmSILAC-validated protein methylation sites
Protein arginine (R) methylation is a post-translational modification that has been shown to play a role in various biological processes, such as RNA splicing, DNA repair, immune response, signal transduction and tumor development. Here, we present a dataset of high-quality methylations obtained fro...
ORGANISM(S): Homo sapiens (Human) 
2022-06-02 | PXD027949 | Pride
Heavy methyl silac Silac Methylation 
ProteomicsTherapeutic targeting of RNA splicing catalysis through inhibition of protein arginine methylation
Cancer-associated mutations in RNA splicing factors commonly occur in myeloid and lymphoid leukemias as well as a variety of solid tumors and confer dependence on wild-type (WT) splicing. These observations have led to clinical efforts to directly inhibit the spliceosome in patients with refractory ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-30 | PXD012007 | Pride
Prmt1 Prmt5 Leukemia Methylation 
UnknownMyelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.
Not available
S-EPMC3809801 | biostudies-literature
UnknownSETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.
Not available
S-EPMC4501574 | biostudies-literature
Proteomics,MultiomicsHematopoietic stem cells (HSCs)
G0 marker-separation of dormant and active hematopoietic stem cells reveals dormancy regulation by basal cytoplasmic calcium
ORGANISM(S): Mus Musculus (mouse) 
2019-12-19 | PXD012093 | JPOST Repository
UnknownInhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization.
Not available
S-EPMC11358161 | biostudies-literature
ProteomicsProteome data on human MDS-L cells
Shotgun mass spectrometric analysis of WT and TOPORS KO MDS-L cells
ORGANISM(S): Homo Sapiens (human) 
2024-03-08 | PXD048275 | JPOST Repository
ProteomicsMS data on ubiquitinated proteins
Mass spectrometric analysis of ubiquitinated proteins in MDS-L cells
ORGANISM(S): Homo Sapiens (human) 
2024-03-08 | PXD044347 | JPOST Repository
UnknownType 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort.
Not available
S-EPMC12284355 | biostudies-literature
UnknownMachine learning models predict long COVID outcomes based on baseline clinical and immunologic factors.
Not available
S-EPMC12764860 | biostudies-literature
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