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ProteomicsPfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
Calcium Dependent Protein Kinases (CDPKs) are key effectors of calcium signaling in malaria parasite. We have elucidated a novel role of PfCDPK1, which is indispensable for the erythrocytic development of Plasmodium falciparum, in invasion of host Red Blood Cells (RBCs). To gain insights into the m...
ORGANISM(S): Plasmodium falciparum 
2017-05-02 | PXD005207 | Pride
Orbitrap fusion Phosphoproteome 
ProteomicsProteomics of Asrij perturbed Drosophila lymph glands as a resource for identification of new regulators of hematopoiesis
Hematological disorders result in perturbed homeostasis of the blood system. However, a comprehensive understanding of how physiological and genetic mechanisms regulate blood cell precursor maintenance and differentiation is lacking. Owing to simplicity and ease of genetic analysis, the Drosophila m...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-05-15 | PXD010753 | Pride
Lymph gland Asrij Differential regulation Escrt Drosophila hematopoiesis Proteome 
ProteomicsA Multi-Omic Analysis of Human Naive CD4 T cells
Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel measurements across thousands of genes and gene products. Such high-throughput technologies have been extensively used to carry out genome-wide studies particularly in the context of disea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-04 | MSV000079624 | MassIVE
ProteomicsCharacterization of human pineal gland proteome
Pineal gland is a neuroendocrine gland located at the center of the brain. It protects the body from the effect of toxic compounds and regulates sleep-wake cycle, body temperature and sexual maturity through the secretion of melatonin. Abnormal functioning of pineal glands is known to be associat...
ORGANISM(S): Homo sapiens (Human) 
2017-02-02 | PXD004332 | Pride
Human Gland Tissue Pineal Lc-ms/ms 
ProteomicsProteogenomics of Candida tropicalis – an opportunistic pathogen
Candida tropicalis is an opportunistic pathogen which causes candidiasis in immune-compromised individuals. It is one of the members of the non-albicans group of Candida that are known to be azole resistant and is frequently seen in individuals being treated for cancers, HIV-infection and bone-marr...
ORGANISM(S): Candida tropicalis (Yeast) 
2017-05-08 | PXD001071 | Pride
Genome annotation Shotgun proteomics 
ProteomicsQuantitative proteomic and phosphoproteomic analysis of H37Ra and H37Rv strains of Mycobacterium tuberculosis
Mycobacterium tuberculosis, the causative agent of tuberculosis accounts for 1.5 million annual deaths worldwide. The two well-characterized strains of the parental H37 strain namely, H37Ra and H37Rv show different pathogenic phenotypes. In order to identify factors that are responsible for virulenc...
ORGANISM(S): Mycobacterium tuberculosis 
2017-05-08 | PXD004161 | Pride
Virulence attenuation Mycobacterium tuberculosis Phosphoproteomics 
ProteomicsGenetic aberrations in MAP kinase pathway play an important role in erlotinib resistance in head and neck cancer
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase is overexpressed in 90% of Head and neck squamous cell carcinoma (HNSCC) patients. Clinical trials with EGFR-targeted tyrosine kinase inhibitors such as erlotinib have shown a modest activity in HNSCC alternate mechanisms of resist...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD007785 | Pride
Head and neck cancer Mass spectrometry Signaling pathways Quantitative phosphoproteomics Egfr-tyrosine kinase inhibitor resistance 
UnknownProteomics-based approach for differentiation of age-related macular degeneration sub-types.
Not available
S-EPMC7942106 | biostudies-literature
ProteomicsSILAC-based quantitative tyrosine phosphoproteomic profiling identifies alternative therapeutic targets to erlotinib in head and neck squamous cell carcinoma
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase is overexpressed in 90% of Head and neck squamous cell carcinoma (HNSCC) patients. Clinical trials with EGFR-targeted tyrosine kinase inhibitors such as erlotinib have shown a modest activity in HNSCC alternate mechanisms of resist...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD007769 | Pride
Head and neck cancer Mass spectrometry Signaling pathways Quantitative proteomics Egfr-tyrosine kinase inhibitor resistance 
UnknownPfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum.
Not available
S-EPMC5498596 | biostudies-literature
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