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ProteomicsSpinal cord phosphoproteome of SCA2/ALS13 mouse model
Toxic polyglutamine (polyQ) expansions in ATXN2 trigger neurodegenerative processes, causing Spinocerebellar Ataxia type 2 (SCA2), and enhancing TDP 43-dependent pathology in Amyotrophic Lateral Sclerosis (ALS) / Fronto-Temporal Dementia (FTD). Primary disease events can be compensated transiently, ...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD062823 | Pride
Fe-nta binding  imac  cortico-spinal motoneurons  cerebellar purkinje neurons  tyrosine receptor endocytosis  intrinsically disordered domains  liquid-liquid phase separation  proteasome  aggrephagy  microtubule-organizing center. 
MetabolomicsChlorophyll biosynthesis under the control of arginine metabolism.

In natural environments, photosynthetic organisms adjust their metabolism to cope with the fluctuating availability of combined nitrogen sources, a growth-limiting factor. For acclimation, the dynamic degradation/synthesis of tetrapyrrolic pigments, as well as of the amino acid arginine, is ...

2024-03-12 | MTBLS8336 | MetaboLights
ProteomicsProteome of WT and CLPP-null Podospora Anserina
Mutations in the gene for the mitochondrial matrix protease CLPP can cause human Perrault syndrome, which is characterized by male and female infertility, progressive sensorineural deafness, ataxia and leukoencephalopathy. This gene encodes a peptidase that is conserved since bacteria and localizes ...
ORGANISM(S): Podospora anserina 
2024-06-22 | PXD048640 | Pride
Clpp Posospora anserina Perrault syndrome 
TranscriptomicsTranscriptional profiling of the sigma factor sigE deletion mutant of Streptomyces coelicolor (J2130) at 0, 30, 60 and 90 minutes after treatment with sub-lethal concentration of vancomycin.
SigE is a sigma factor found in Streptomyces species and is the key regulator of cell envelope stress response in Streptomyces coelicolor. To determine the regulon of SigE under conditions of cell envelope stress, 10 ug / ml vancomycin was used to induce cell envelope stress in the wild type and a s...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2019-04-24 | E-MTAB-7814 | biostudies-arrayexpress
GenomicsIdentification by ChIP-Seq of the binding sites of the extracytoplasmic function (ECF) sigma factor SigE in the genome of Streptomyces coelicolor A3(2) M600.
SigE is a sigma factor found in Streptomyces species and is the key regulator of cell envelope stress response in Streptomyces coelicolor. This ChIP-Seq experiment was carried out to determine the binding sites of SigE under conditions of cell envelope stress induced by 10 ug / ml vancomycin for 30...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2019-04-24 | E-MTAB-7827 | biostudies-arrayexpress
ProteomicsComplexome profiling of testis tissue in WT and ClpP-/- mice
Mutations in the gene for the mitochondrial matrix protease CLPP can cause human Perrault syndrome, which is characterized by male and female infertility, progressive sensorineural deafness, ataxia and leukoencephalopathy. This gene encodes a peptidase that is conserved since bacteria and localizes ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD035352 | Pride
Protease function Complexome profiling 
ProteomicsComplexome profiling of brain mitochondria from WT and ClpP-/- mice
Mutations in the gene for the mitochondrial matrix protease CLPP can cause human Perrault syndrome, which is characterized by male and female infertility, progressive sensorineural deafness, ataxia and leukoencephalopathy. This gene encodes a peptidase that is conserved since bacteria and localizes ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD036901 | Pride
Protease function Complexome profiling 
ProteomicsComplexome profiling of heart mitochondria from WT and ClpP-/- mice
Mutations in the gene for the mitochondrial matrix protease CLPP can cause human Perrault syndrome, which is characterized by male and female infertility, progressive sensorineural deafness, ataxia and leukoencephalopathy. This gene encodes a peptidase that is conserved since bacteria and localizes ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD036933 | Pride
Protease function Complexome profiling 
UnknownSELEX based aptamers with diagnostic and entry inhibitor therapeutic potential for SARS-CoV-2.
Not available
S-EPMC10477244 | biostudies-literature
ProteomicsRumen microbiome and effect of monensin
The time-resolved impact of monensin on the active rumen microbiome in a rumen-simulating technique (Rusitec) was studied with metaproteomic and metabolomic approaches. Upon monensin treatment, decreased catabolism linked to fiber degradation was observed by the reduced abundance of proteins assigne...
ORGANISM(S): Bos taurus (Bovine) 
2022-12-11 | PXD034099 | Pride
Prevotella Microbiome Monensin Rumen 
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