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ProteomicsBiopsy proteome-based classification of T-cell-mediated kidney allograft rejection
T cell-mediated rejection (TCMR) remains a challenge in kidney transplantation. Based on a histopathological biopsy examination, patients can be classified into groups defining their kidney’s status, i.e. no rejection (NR), borderline rejection (BR) and acute rejection (AR). Yet, this classification...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD064523 | Pride
Borderline rejection Kidney transplant rejection Immunohistochemical staining T-cell mediated rejection Mass spectrometry proteomics 
ProteomicsProteomic analysis of differentially expressed proteins in the serum of patients with acute renal allograft rejection using iTRAQ labelling technology
Transplantation is currently the best treatment option for end-stage renal disease (ESRD) patients. However, acute rejection (AR) is the main source of failure in renal transplantation. The current gold standard for diagnosis of AR involves renal biopsy, but it is invasive, time consuming, costly an...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015336 | Pride
Proteomics Acute rejection Serum Renal allograft Itraq 
ProteomicsTarget search for self-reactive antibodies in human renal allograft rejection
Self-reactive antibodies cloned from B cells infiltrating in a human renal allograft were subjected to IP-mass spectrometry using nuclear lysates of HEp-2 cells.
ORGANISM(S): Homo sapiens (Human) 
2021-04-27 | PXD022989 | Pride
Keywords: renal allograft rejection Transcription Q-exactive Inflammation Scrna-seq Human Human Innate b cells Autoantibodies Lfq Tolerance 
ProteomicsFat1 is atarget antigen in de novo allograft membranous nephropoathy associated with antibody mediated rejection.
Membranous nephropathy (MN) occurs either as recurrent or de novo MN in the kidney allograft. Recurrent MN is most often associated with antibodies to the target antigen M-type phospholipase A2 receptor (PLA2R). 1-3 Most cases of de novo MN are PLA2R-negative and the target antigen in unknown.2 We h...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD055559 | Pride
Kidney transplant. Fat1 De novo membranous nephropathy 
TranscriptomicsResveratrol prevents corneal allograft rejection in the rat cornea
Rat corneal allograft rejection models were established to investigate the effects and mechanisms of resveratrol on corneal allograft rejection after corneal transplantation.
ORGANISM(S): Rattus norvegicus 
2023-07-10 | GSE236626 | GEO
ProteomicsBiomarker identification of lung allograft rejection
this project aim to identify potential protein biomarker from plasma extracellular vesicles to distinguish lung allograft rejection from pulmonary infection.
ORGANISM(S): Homo Sapiens 
2026-08-20 | PXD083053 |
TranscriptomicsIdentifying the genes involved in CD4+ T cell mediated-acute allograft rejection
Acute allograft rejection is a leading cause for the failure of organ allotransplantation. Identifying the genes involved in the rejection process provides clues to study the mechanisms, and to provide specific gene targets for monitoring, predicting and preventing acute allograft rejection. Using a...
ORGANISM(S): Mus musculus 
2010-03-01 | GSE14540 | GEO
TranscriptomicsBlocking hyaluronan synthesis alleviates acute lung allograft rejection.  
Lung allograft rejection results in the accumulation of low molecular weight hyaluronic acid (LMW-HA), which further propagates inflammation and tissue injury. We have previously shown that therapeutic lymphangiogenesis in a murine model of lung allograft rejection reduced tissue LMW-HA and was asso...
ORGANISM(S): Mus musculus 
2021-12-15 | GSE183142 | GEO
TranscriptomicsMolecular heterogeneity in acute renal allograft rejection
The data set contains 67 array (lymphochip cDNA array), published in N Engl J Med 2003 Jul 10;349(2):125-38. PMID: 12853585. TITLE: Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. BACKGROUND: The causes and clinical course of acute rejection vary, a...
ORGANISM(S): Homo sapiens 
2003-07-01 | GSE343 | GEO
TranscriptomicsMolecular profiling of anemia in acute renal allograft rejection
Compromised renal function after renal allograft transplantation often results in anemia in the recipient. Molecular mechanisms leading to anemia during acute rejection are not fully understood; inadequate erythropoietin production and iron deficiency have been reported to be the main contributors. ...
ORGANISM(S): Homo sapiens 
2006-01-06 | GSE3976 | GEO
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