Killinger Bryan A BA

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Proteomics (4)

Organisms

Lactococcus cremoris subsp. cremoris MG1363 (4)
uncultured Clostridium sp. (4)
Toxoplasma gondii PRU (4)
Malus domestica (4)
Desulforapulum autotrophicum HRM2 (4)
Polaribacter marinivivus (4)
Diplonema (4)
Diplonema papillatum (4)
Mytilus californianus (4)
Cryptococcus neoformans H99-YPD_1 (4)
Leptopilina heterotoma (4)
Palaemon carinicauda (4)
Nannochloropsis oculata (4)
Mycobacterium tuberculosis KT-0001 (4)
Bacillus subtilis TPK 210909 (4)
Pelagomonas calceolata (4)
Escherichia coli BL21 (4)
Tetraselmis suecica (4)
Kamptonema sp. (4)
Trichoderma reesei (4)
Saccharolobus islandicus LAL14/1 (4)
Musa ABB Group (4)
Plasmodium yoelii (4)
Notamacropus eugenii (4)
Mycobacterium tuberculosis LAM7 (4)
Mycobacterium tuberculosis variant bovis str. Ravenel (4)
Mycobacterium tuberculosis CAS (4)
Clarias magur (4)
Mycobacterium avium 100 (4)
Pseudomonas aeruginosa ATCC 700888 (4)

Repository

pride (4)

Tissue

Brain (4)

Disease

Parkinson's disease (2)
Lewy body dementia (1)
Disease free (1)

Technology Type

Affinity purification coupled with mass spectrometry proteomics (4)
Mass Spectrometry (4)
Shotgun proteomics (1)

Publication Date

2025 (1)
2024 (1)
2023 (1)
2022 (1)

Lab affiliation

Rush University Medical Center (2)
Assisstant professor. Graduate College. Rush University Medical Center. (1)
Graduate College and Department of Neurology Rush University Medical Center (1)

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Does alpha synuclein strain or GCase enzyme activity drive clinical aggression in GBA-PD?

Parkinson’s disease (PD) is a neurodegenerative disease characterized by progressive motor symptoms and alpha-synuclein (αsyn) aggregation in the nervous system. For unclear reasons, PD patients with certain GBA mutations (GBA-PD) have a more aggressive clinical progression. Two testable hypotheses ...

ORGANISM(S): Mus musculus (Mouse)

2024-02-22 | PXD045437 | Pride

Comparison of MSA with PD/DLB alpha-synuclein pathology using proximity proteomics

Multiple systems atrophy (MSA) is a unique synucleinopathy of unknown cause characterized by alpha-synuclein aggregates in oligodendroglia. Here, we used the in-situ proximity labeling technique biotinylation (BAR) by antibody recognition to identify alpha-synuclein interactomes in the MSA brain and...

ORGANISM(S): Homo sapiens (Human)

2025-03-27 | PXD055305 | Pride

Alpha-synuclein Interactome

In Situ Proximity Labeling Identifies Lewy Pathology Molecular Interactions in the Human Brain

The intracellular misfolding and accumulation of alpha-synuclein into structures collectively called LP is a central phenomenon for the pathogenesis of synucleinopathies including Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Understanding the molecular architecture of LP is crucial ...

ORGANISM(S): Homo sapiens (Human)

2022-02-22 | PXD028830 | Pride

In situ Biotinylation by antigen recognition Neuropathology Lewy pathology Alpha-synuclein

Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis.

Project aim was to identify protein-protein interactions of the post-translationally modified form of alpha-synuclein. In situ proximity labeling (BAR) was used to enrich for protein-protein interactions. We performed BAR on wild-type and alpha-synuclein knockout olfactory bulb tissues. We include n...