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MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
TranscriptomicsHIV-specific B cells are enriched within abnormal memory subsets in infected individuals
Recently, several neutralizing anti-HIV antibodies have been isolated from memory B cells of HIV-infected individuals. However, despite extensive evidence of B-cell dysfunction in HIV disease, little is known about the cells from which these rare HIV-specific antibodies originate. Accordingly, HIV e...
ORGANISM(S): Homo sapiens 
2014-06-24 | E-GEOD-56499 | biostudies-arrayexpress
ProteomicsProteome of lysate granules using G3BP and ASPL, and changes in the G3BP interactome caused by ASPL depletion
Proteome of lysate granules using G3BP and ASPL, and changes in the G3BP interactome caused by ASPL depletion
ORGANISM(S): Homo sapiens (Human) 
2025-08-16 | PXD059889 | Pride
Ribonucleoprotein granule Aspscr1 Ubxd9 Tug Protein homeostasis Viscoelasticity Aspl Stress granule Rheology Vcp/p97 G3bp Ulk Multisystem proteinopathy 
TranscriptomicsNodal Root Bud Development - Transcriptome Analysis
Bioenergy sorghum’s large and deep nodal root system and associated microbiome enables uptake of water and nutrients from and deposition of soil organic carbon into soil profiles, key contributors to the crop’s resilience and sustainability. The goal of this study was to increase our understanding o...
ORGANISM(S): Sorghum bicolor 
2025-05-10 | E-MTAB-15090 | biostudies-arrayexpress
UnknownA role for Cep70 in centriole amplification in multiciliated cells.
Not available
S-EPMC7856201 | biostudies-literature
MetabolomicsAzithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation
Administration of azithromycin after allogeneic hematopoietic stem cell transplantation for hematological malignancies has been associated with relapse in a randomized phase 3 controlled clinical trial. Studying 240 samples from patients randomized in this trial is a unique opportunity to better und...
2022-08-22 | MTBLS406 | MetaboLights
TranscriptomicsAkt-Induced Mitochondrial Dysfunction in the Heart
Sustained Akt activation induces cardiac hypertrophy (LVH), which may lead to heart failure. This study tested the hypothesis that Akt activation contributes to mitochondrial dysfunction in pathological LVH. Akt activation induced LVH and progressive repression of mitochondrial fatty acid oxidation ...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-63848 | biostudies-arrayexpress
TranscriptomicsPathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma
Polymorphisms in the interleukin-4 receptor ? chain (IL-4R?) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of IL-4R? has been associated with severe asthma, especially i...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-18010 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human head and neck squamous cell carcinomas that are positive or negative for Human Papilloma Virus
Introduction: Human Papilloma Virus (HPV) is associated with a subset of head and neck squamous cell carcinoma (HNSCC), between 15% and 35% of HNSCC harboring HPV, almost exclusively of subtype 16. Demographic and exposure differences between HPV-positive (+) and negative (-) HNSCCs suggest that HPV...
ORGANISM(S): Homo sapiens 
2007-09-20 | E-GEOD-3292 | biostudies-arrayexpress
TranscriptomicsWTX interacts with the transcriptional regulator TRIM28 to mediate cellular differentiation
WTX encodes a tumor suppressor implicated in Wilms tumor and in mesenchymal differentiation, with distinct functions in the cytoplasm, at the plasma membrane and in the nucleus. Here we report that the transcriptional corepressor TRIM28 is the major binding partner for nuclear WTX. The WTX-TRIM28 in...
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-60418 | biostudies-arrayexpress
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