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ProteomicsSIRT6 and SIRT7 binding proteome
To find the SIRT6 and SIRT7 binding proteins, we expressed V5-tagged SIRT6 and SIRT7 and pulled down this protein with anti-V5 agarose affinity gel. Sirtuins are a family of NAD-dependent deacetylases which deacetylate not only histones but also a wide range of target proteins. Sirtuins are conserve...
ORGANISM(S): Homo sapiens (Human) 
2014-04-28 | PXD000159 | Pride
Sirt7 Sirt6 Lc-ms/ms 
ProteomicsSIRT_mutant interactome - Comparative interactomes of SIRT6 and SIRTimplication of functional links to aging
In the present study, we identified SIRT6 (S56Y)- and SIRT7 (H187Y)-interacting proteins, and compared their interactomes to investigate functional links.
Extra primary submitter: Namgyu Lee, Department of Life Sciences, Pohang University of ...
ORGANISM(S): Homo sapiens (Human) 
2014-04-28 | PXD000850 | Pride
Sirt7 Mutant Sirt6 
ProteomicsComparative interactomes of VRK1 and VRK3: implication in cell cycle, chromatin assembly, RNA processing and DNA repair
Vaccinia related kinase (VRK) family is a ser/threonine kinase. VRK1 and VRK3 are localized in the same organelle, mainly in the nucleus. Comparative interactomes of VRK1 and VRK3 were not performed yet. We identified over 200 unreported VRK1/3-interacting proteins by proteomics-based analyses using...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD004103 | Pride
Vrk1 Interactome Vrk3 
ProteomicsREST-interactome - Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation
Namgyu Lee has participated in the experimental part of this project and she is a co-first author of the under-going manuscript. RE-1 silencing transcription factor (REST) is a transcriptional repressor with a role in regulating gene expression through binding to repressor element 1. We identified R...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003210 | Pride
Interaction profiling Cell biology Proteomics Transcription factor Lc-ms/ms 
ProteomicsTwo distinct extracellular protein signatures released by a single cell type identified by LC-MS/MS
Cells secrete extracellular RNA (exRNA) to their surrounding environment and exRNA has been found in many body fluids such as blood, breast milk and cerebrospinal fluid. However, there are conflicting results regarding the nature of exRNA. Here, we have separated two distinct exRNA profiles release...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD004931 | Pride
Exosome 
ProteomicsProteomics of extracellular vesicle after SDCBP knockout
To see the role of SDCBP for protein recruitment into extracellular vesicle, we did comparative EV proteomic before and after SDCBP knockout.
ORGANISM(S): Homo sapiens (Human) 
2019-12-02 | PXD012321 | Pride
Sdcbp Extracellular vesicle 
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