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TranscriptomicsTranscription profiling of mouse ES cells, neural precursor cells and embryonic fibroblasts
Expression profiles for isogenic (129SvJae x C57BL/6) murine embryonic stem (ES) cells, neural precursors (NPC) obtained through in vitro differentiation of the ES cells, and embryonic fibroblasts (MEF) obtained at day 13.5. Experiment Overall Design: 3 replicates of wt ES cells, 3 replicates of wt...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8024 | biostudies-arrayexpress
TranscriptomicsIllumina gene expression beadchips of human ES cell lines
Publication title: Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver To investigate the role of DNA methylation during human development, we developed Methyl-seq, a method that assays DNA methylation at more than 90,000 regions...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-29070 | biostudies-arrayexpress
GenomicsHigh-throughput sequencing of ES cell lines, ES-derived cells, and fetal and normal livers
Publication title: Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver To investigate the role of DNA methylation during human development, we developed Methyl-seq, a method that assays DNA methylation at more than 90,000 regions...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-29071 | biostudies-arrayexpress
ProteomicsIKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia
Genome-scale functional genetic screening was utilized to identify resistance mechanisms and synthetic lethal interactions during small molecule targeting of MENIN and DOT1L in MLL1-rearranged AML. Chromatin regulatory complexes are found to modulate the therapeutic response to these inhibitors, and...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD025271 | Pride
Ikzf1 Kmt2a Menin Mll1 Ikaros Acute myeloid leukemia Dot1l Imid Lenalidomide Men1 
ProteomicsIKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia
Genome-scale functional genetic screening was utilized to identify resistance mechanisms and synthetic lethal interactions during small molecule targeting of MENIN and DOT1L in MLL1-rearranged AML. Chromatin regulatory complexes are found to modulate the therapeutic response to these inhibitors, and...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD025272 | Pride
Ikzf1 Kmt2a Menin Mll1 Ikaros Acute myeloid leukemia Dot1l Imid Lenalidomide Men1 
ProteomicsIKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia
Genome-scale functional genetic screening was utilized to identify resistance mechanisms and synthetic lethal interactions during small molecule targeting of MENIN and DOT1L in MLL1-rearranged AML. Chromatin regulatory complexes are found to modulate the therapeutic response to these inhibitors, and...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD025229 | Pride
Ikzf1 Kmt2a Menin Mll1 Ikaros Acute myeloid leukemia Dot1l Imid Lenalidomide Men1 
ProteomicsIKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia
Genome-scale functional genetic screening was utilized to identify resistance mechanisms and synthetic lethal interactions during small molecule targeting of MENIN and DOT1L in MLL1-rearranged AML. Chromatin regulatory complexes are found to modulate the therapeutic response to these inhibitors, and...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD025228 | Pride
Ikzf1 Kmt2a Menin Mll1 Ikaros Acute myeloid leukemia Dot1l Imid Lenalidomide Men1 
ProteomicsIKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia
Genome-scale functional genetic screening was utilized to identify resistance mechanisms and synthetic lethal interactions during small molecule targeting of MENIN and DOT1L in MLL1-rearranged AML. Chromatin regulatory complexes are found to modulate the therapeutic response to these inhibitors, and...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD025227 | Pride
Ikzf1 Kmt2a Menin Mll1 Ikaros Acute myeloid leukemia Dot1l Imid Lenalidomide Men1 
ProteomicsIKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia
Genome-scale functional genetic screening was utilized to identify resistance mechanisms and synthetic lethal interactions during small molecule targeting of MENIN and DOT1L in MLL1-rearranged AML. Chromatin regulatory complexes are found to modulate the therapeutic response to these inhibitors, and...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD025232 | Pride
Ikzf1 Kmt2a Menin Mll1 Ikaros Acute myeloid leukemia Dot1l Imid Lenalidomide Men1 
ProteomicsIKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia
Genome-scale functional genetic screening was utilized to identify resistance mechanisms and synthetic lethal interactions during small molecule targeting of MENIN and DOT1L in MLL1-rearranged AML. Chromatin regulatory complexes are found to modulate the therapeutic response to these inhibitors, and...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD025231 | Pride
Ikzf1 Kmt2a Menin Mll1 Ikaros Acute myeloid leukemia Dot1l Imid Lenalidomide Men1 
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