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ProteomicsIn-depth proteome analysis of peritoneal tissues in mouse peritoneal dialysis model
Peritoneal fibrosis is the main cause of dialysis modality change to hemodialysis in peritoneal dialysis patients. We conducted an in-depth proteomics for peritoneal tissue with and without cyclo Histidine-Proline (Cyclo His-Pro, CHP) administration to determine protective effect of CHP on peritonea...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-26 | PXD037403 | Pride
Mouse Peritoneal tissue Peritoneal dialysis Lc-ms/ms 
ProteomicsProteomic analysis of Prote-a-Tac
The 26S proteasome recognizes substrates via ubiquitin receptors, a mechanism we leveraged to develop a small molecule ligand- and ubiquitination-independent targeted protein degradation strategy. Our proteasome-targeting chimera, Prote-a-Tac, links a proteasomal Ub receptor (PSMD4 or ADRM1) with a ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD063133 | Pride
Tmt Degradation Proteasome 
ProteomicsMetabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis
A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the “Warburg effect”, which is also observed in primed human pluripotent stem cells (hPSCs). Here, we report that downregulation of SIRT2 and upregulation of SIRT1 is...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD006036 | Pride
Acetylation Sirt2 Differentiation Human pluripotent stem cells 
UnknownFully automated segmentation and classification of renal tumors on CT scans via machine learning.
Not available
S-EPMC11781067 | biostudies-literature
UnknownAssociation between decreased ipsilateral renal function and aggressive behavior in renal cell carcinoma.
Not available
S-EPMC9639309 | biostudies-literature
UnknownNeuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction.
Not available
S-EPMC6238202 | biostudies-literature
UnknownEpidemiology and Trends of Obesity and Bariatric Surgery in Korea.
Not available
S-EPMC11525690 | biostudies-literature
UnknownNine-day continuous recording of EEG and 2-hour of high-density EEG under chronic sleep restriction in mice.
Not available
S-EPMC9126869 | biostudies-literature
ProteomicsCTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks
The pleiotropic CCCTC-binding factor (CTCF) plays a role in homologous recombination (HR) repair of DNA double-strand breaks (DSBs). However, the precise mechanistic role of CTCF in HR remains largely unclear. Here, we show that CTCF engages in DNA end resection, which is the initial, crucial step i...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD014441 | Pride
Pleiotropic ccctc-binding factor Mre11 Human Interactome 
UnknownCould Peer Support Programs Be a Good Resource for Managing the Unmet Needs of Cancer Patients?
Not available
S-EPMC6785582 | biostudies-literature
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