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MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
ProteomicsMass spectrometry-based proteomics discovery of prognostic biomarkers in adrenal cortical carcinoma
Adrenal cortical carcinoma (ACC) is an extremely rare disease with a variable prognosis. Current prognostic markers have limitations in identifying patients with a poor prognosis. Herein, we aimed to investigate the prognostic protein biomarkers of ACC using mass-spectrometry-based proteomics. We pe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-07 | PXD027404 | Pride
Human Ffpe Lfq Adrenal cortical carcinoma Biomarkers 
ProteomicsTissue extracellular matrix hydrogels as alternative to Matrigel for culturing gastrointestinal organoids
Matrigel, a mouse tumor extracellular matrix (ECM) protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to batch variation, high cost, and...
ORGANISM(S): Sus scrofa (Pig) Mus musculus (Mouse) 
2022-02-10 | PXD023694 | Pride
Organoid Matrigel Lc-ms/ms 
ProteomicsIn-depth quantitative proteomic analysis of rat cardiac tissue for exploring potential mediators of early cardiac reaioablation effect
Recently, stereotactic ablative radiotherapy (SABR) is adopted to noninvasively treat catheter ablation-refractory ventricular tachycardia (VT). VT episodes were dramatically reduced after SABR within few weeks, but underlying mechanisms of these clinical effects as well as potential mediator of ear...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-08-12 | PXD030878 | Pride
Rat Tmt Cardiac tissue Radiotherapy 
ProteomicsQuantitative proteomic analysis of urine liquid biopsy samples in muscle invasive bladder urothelial carcinoma
We performed mass spectrometry-based proteomic analysis of urine samples of patients with BLCA with stroma invasion or muscle invasion to identify prognosis markers for use in liquid-based cytology (LBC).
ORGANISM(S): Homo sapiens (Human) 
2020-04-29 | PXD016437 | Pride
Human Lable free quantification Cytology Urothelial carcinoma Urine 
Proteomicsquantitative proteomic analysis of proteasome in response to MG132
The ubiquitin-proteasome system and autophagy are two major intracellular proteolytic pathways and both remove misfolded and proteotoxic proteins from eukaryotic cells. This study describes the detailed informations about the change in composition and interactome of proteasomes after prolonged MG132...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019193 | Pride
Proteasome Interactome Mg132 
ProteomicsTranscriptome and proteome analysis of the human corneal endothelium and aqueous humor reveal endothelial cell dysfunction markers
Background: The underlying mechanism as well as diagnostic molecular biomarkers for corneal endothelial cell dysfunction (CECD) remain elusive. This study aimed to elucidate molecular mechanism of CECD via proteomic and transcriptomic approaches and identify novel biomarkers in aqueous humor (AH) di...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD023772 | Pride
Proteomics Aqueous humor Corneal endothelial cell dysfunction Transcriptomics Biomarker Bullous keratopathy 
ProteomicsProteome datasets for root‑preferential OsPUB36 modulates ROS levels and regulates root development
Root development is tightly regulated by spatial gradients of reactive oxygen species (ROS), which coordinate transitions from cell division to elongation and differentiation. Through phylogenetic meta-analysis, we identified a root-preferential subclass of class III PUB E3 ubiquitin ligases (OsPUB3...
ORGANISM(S): Oryza sativa (Rice) 
2026-10-07 | PXD067944 | Pride
Tandem mass tags Ros homeostasis Rice root E3 ubiquitin ligase Lc-ms/ms 
UnknownDHP-derivative and low oxygen tension effectively induces human adipose stromal cell reprogramming.
Not available
S-EPMC2817727 | biostudies-literature
ProteomicsMetabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis
A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the “Warburg effect”, which is also observed in primed human pluripotent stem cells (hPSCs). Here, we report that downregulation of SIRT2 and upregulation of SIRT1 is...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD006036 | Pride
Acetylation Sirt2 Differentiation Human pluripotent stem cells 
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