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ProteomicsPathological changes in extracellular matrix composition orchestrate the fibrotic feedback loop through macrophage activation in Dupuytren’s contracture
Dupuytren’s contracture belongs to a large group of fibrotic diseases that share similar mechanisms but lack effective treatment and prevention options. Unlike fibrotic diseases affecting internal organs such as the heart, lung or liver which are typically diagnosed at later stages when the function...
ORGANISM(S): Homo sapiens (Human) 
2025-03-29 | PXD059943 | Pride
Dupuytren's contracture Fibrosis Extracellular matrix Decellularization 
ProteomicsProliferation, migration and inflammation-related signaling pathways activated in THBS4-stimulated keratinocytes characterize both wound healing and atopic dermatitis
Atopic dermatitis, which is a common inflammatory skin disease characterized by persistent epidermal barrier dysfunction, is a systemic health burden reducing overall quality of life of the person. Recently, we showed that the nonstructural extracellular matrix molecule Thrombospondin-4 (THBS4) was ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-29 | PXD037593 | Pride
Thbs4 Thrombospondin-4 Skin Keratinocytes Atopic dermatitis 
ProteomicsLichtenberg figures in high voltage electrical injury
Lichtenberg figures (LF), also known as a ferning pattern or keraunographic marking, is a pathognomonic skin sign for a lightning strike injury. The true pathophysiology of LF remains unknown. This dataset describes a case of LF following a high voltage electrical injury in which a skin biopsy was t...
ORGANISM(S): Homo sapiens (Human) 
2021-05-28 | PXD011532 | Pride
Tissue response Lactoferrin Lichtenberg figures Electric injury 
ProteomicsConnective tissue regeneration dynamics persistently alter epithelial dynein DNAH10 expression - DNAH10 overexpression in psoriatic lesional epidermis
The objective of this study was to investigate how active dermal connective tissue composition dynamics affect long term protein expression in the epidermis. After surgically removing damaged skin to its full thickness at the site of a deep burn in ten patients, we randomized three adjacent test are...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010852 | Pride
Human Skin Dermis Burn injury Label-free quantification Epidermis 
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