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MetabolomicsMulti-dimensional leaf phenotypes reflect root system genotype in grafted grapevine over the growing season

BACKGROUND: Modern biological approaches generate volumes of multi-dimensional data, offering unprecedented opportunities to address biological questions previously beyond reach owing to small or subtle effects. A fundamental question in plant biology is the extent to which below...

2022-01-07 | MTBLS2831 | MetaboLights
ProteomicsDecoding the molecular complexity governing corneal wound closure in vivo
The cornea is the transparent tissue on the anterior surface of the eye. It is notably composed of a squamous stratified epithelium that forms a barrier protecting the ocular chamber. As the cornea is avascular, the delivery of nutrients and growth factors, required for corneal physiology, is essent...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD061492 | Pride
Epithelium Proteomics Cornea Lacrimal gland Epitranscriptomics Tears Transcriptomics 
TranscriptomicsTranscription profiling of human frozen tumor biopsies from diffuse large cell lynohoma patients reveals mutations of multiple genes deregulate the NF-kB pathway in diffuse large B cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma in adulthood, comprises multiple biologically and clinically distinct subtypes including germinal center B cell-like (GCB) and activated B cell like (ABC) DLBCL. Gene expression profile studies have shown that its most aggressiv...
ORGANISM(S): Homo sapiens 
2009-04-19 | E-GEOD-12195 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HT1080 fibrosarcoma cells treated with cytostatic drugs
HT1080 fibrosarcoma cells were treated with cytostatic drugs and analysed on Affymetrix microarray to identify genes and pathways regulated by these compounds. The array images were processed using Affymetrix MAS 5.0 software. and normalized by global scaling or scaled to a polyA+ spike mask
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-2238 | biostudies-arrayexpress
UnknownReplicating state Quitline innovations to increase reach: findings from three states.
Not available
S-EPMC6945575 | biostudies-literature
MetabolomicsGlycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, coun...
2024-02-07 | MTBLS6847 | MetaboLights
GenomicsIdentification of MLL2 regulated genes in germinal center B cells
Somatic mutations of the MLL2 methyltransferase gene represent a common genetic lesion in multiple cancer types. In diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL), these mutations are highly recurrent and occur early during tumorigenesis, suggesting a central role in transformati...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-67494 | biostudies-arrayexpress
TranscriptomicsTREM2 regulates microglial cell activation in response to demyelination in vivo
Microglia are phagocytic cells that survey the brain and perform neuroprotective functions in response to tissue damage, but their activating receptors are largely unknown. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in hum...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-70475 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of single circulating tumor cells with diagnostic intention
About 230 clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but no assays enable comprehensive molecular characterization of CTCs with diagnostic precision. We therefore combined a workflow for CTC enrichment and isolation with 100% purity wit...
ORGANISM(S): Homo sapiens 
2014-11-05 | E-GEOD-58192 | biostudies-arrayexpress
TranscriptomicsWhole-exome sequencing identifies mutations of BCOR in acute myeloid leukemia with normal karyotype
Among acute myeloid leukemias (AML) with normal karyotype (CN-AML), NPM1 and CEBPA mutations define WHO provisional entities accounting for ~60% of cases, but the remaining ~40% remains poorly characterized. By whole exome-sequencing (WES) of one CN-AML patient lacking mutations in NPM1, CEBPA, FLT3...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-30442 | biostudies-arrayexpress
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