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TranscriptomicsExpression data from mouse liver
HBV-transgenic mice were treated i.v. with 1x10e11 particles AAV serotype 8 vectors expressing different RNAi-triggers targeting the HBV transcripts. To determine possible toxicities caused by the different vectors (including off-target activity against endogenous genes) we performed a whole transcr...
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-72335 | biostudies-arrayexpress
GenomicsEngineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus
Short hairpin RNA (shRNA) expression strategies that allow safe and persistent target mRNA knockdown are key to the success of many in vitro or in vivo RNAi applications. Here, we propose a novel solution which is expression of a promoterless miRNA-adapted shRNA (shmiRNA) from an engineered genomic ...
EGAS00001001252 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-01-06-2015-13:43:18:542-193 - samples
Whole Genome Sequencing of Huh7 cell lines
EGAD00001001386 | EGA
GenomicsBioinformatics of Data Analysis (B240)
Data Access Committee EGAC00001000346
EGAC00001000346 | EGA
TranscriptomicsIntra-individual genome expression analysis reveals a specific molecular signature of psoriasis and eczema
Comparing molecular signatures of psoriasis and eczema in patients co-affected by both diseases provides a comprehensive understanding of disease pathogenesis as well as a diagnostic tool to differentiate these widespread inflammatory skin diseases. In patients affected by both psoriasis and non-ato...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-57225 | biostudies-arrayexpress
TranscriptomicsClinically non-involved skin of patients with psoriasis, lichen planus, and healthy individuals
To investigate differences in the kinetics of allergic contact dermatitis reactions in psoriasis patients, molecular changes in clinically non-involved skin of psoriasis patients was investigated whole genome expression arrays of clinically non-involved skin of psoriasis (n=8), lichen planus (n=3), ...
ORGANISM(S): Homo sapiens 
2014-05-31 | E-GEOD-58121 | biostudies-arrayexpress
ProteomicsQuantitative Myogenesis C2C12 Proteome with Dimethyl-Labelling
The Z-disc is a protein-rich structure critically important for myofibril development and integrity. In order to monitor the quantiative changes in C2C12 myoblast during myogenesis, a quantitative dimethyl-labelling approach was performed with d0 myoblasts, d5 myotubes and electrical puls stimulated...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-02 | PXD004960 | Pride
Muscle differentiation Myoblasts Dimethyl C2c12 cells Myotubes 
ProteomicsCharting Organellar Importomes by Quantitative Mass Spectrometry - ATOM40 whole cells
Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analyzing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting ou...
ORGANISM(S): Trypanosoma brucei 
2017-06-14 | PXD005725 | Pride
Trypanosoma brucei Proteomics Glycosomes Organellar protein import Mitochondria Silac Importomics Rnai-mediated protein knockdown 
ProteomicsCharting Organellar Importomes by Quantitative Mass Spectrometry - ATOM40p
Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analyzing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting ou...
ORGANISM(S): Trypanosoma brucei 
2017-06-14 | PXD004917 | Pride
Trypanosoma brucei Proteomics Glycosomes Organellar protein import Mitochondria Silac Importomics Rnai-mediated protein knockdown 
ProteomicsCharting Organellar Importomes by Quantitative Mass Spectrometry – ATOM40c
Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analyzing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting ou...
ORGANISM(S): Trypanosoma brucei 
2017-06-14 | PXD004950 | Pride
Trypanosoma brucei Proteomics Glycosomes Organellar protein import Mitochondria Silac Importomics Rnai-mediated protein knockdown 
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