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ProteomicsMultistep mechanism of G-quadruplex resolution during DNA replication
G-quadruplex (or G4) structures are non-canonical DNA structures that form in guanine-rich sequences and threaten genome stability when not properly resolved. G4 unwinding occurs during S phase via an unknown mechanism. Using Xenopus egg extracts, we define a three-step G4 unwinding mechanism that a...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-17 | PXD027623 | Pride
G4 resolution G-quadruplex Helicases Dhx36 G4 Fancj Dna replication 
ProteomicsDNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions that block essential cellular processes like replication and transcription. Endogenous ICLs can be induced by reactive aldehydes produced during normal cellular metabolism. Defective repair of these aldehyde-induced ICLs is associated wi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-29 | PXD062134 | Pride
Acrolein-icl Fa pathway Acetaldehyde-icl Polymerase kappa Translesion synthesis 
ProteomicsCell cycle phosphorylation dynamics in vivo reveals switch-like control of intrinsic disorder
Switch-like cyclin-dependent kinase (CDK)-1 activation is thought to underlie the abruptness of mitotic onset, but how CDKs can simultaneously phosphorylate many diverse substrates is unknown, and direct evidence for such phosphorylation dynamics in vivo is lacking. Here, we analysed protein phospho...
ORGANISM(S): Xenopus Laevis 
2023-10-13 | PXD026088 | panorama
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