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TranscriptomicsExpression data from Arabidopsis wild-type, KO-nudx6, KO-nudx7, and double KO-nudx6/7 plants
Arabidopsis Nudix hydrolases, AtNUDX6 and 7, exhibit pyrophosphohydrolase activities toward NADH and contribute to the modulation of various defense responses, such as the poly(ADP-ribosyl)ation (PAR) reaction and salicylic acid (SA)-induced Nonexpresser of Pathogenesis-Related genes 1 (NPR1)-depend...
ORGANISM(S): Arabidopsis thaliana 
2015-10-28 | E-GEOD-74346 | biostudies-arrayexpress
TranscriptomicsExpression data from Arabidopsis wild-type (Col-0) and KO-nudx19 plants, which lacks nudix hydrolase 19, a NADPH hydrolase
The NADPH status, which is regulated by AtNUDX19, a NADPH pyrophosphohydrolase, is involved in the regulation of stress and hormonal responses. To clarify how the status is involved in the regulation, we performed a microarray analysis using 3-week-old wild-type and KO-nudx19 leaves grown under norm...
ORGANISM(S): Arabidopsis thaliana 
2015-01-15 | E-GEOD-64968 | biostudies-arrayexpress
MetabolomicsThe impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes
We showed earlier that nutritional stress like starvation or high fat diet resulted in phenotypic changes in the lipidomes of hepatocyte lipid droplets (LDs), representative for the pathophysiological status of the mouse model. Here we extend our former study by adding genetic stress due to knock-ou...
2014-08-19 | MTBLS81 | MetaboLights
MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
ProteomicsLFQ shotgun proteomic analysis of HAP1 NatC KO cells
The impact of NatC subunits NAA30, NAA35 and NAA38 on the human proteome (protein abundance). Analysis of HAP1 WT, NAA30 KO, NAA35 KO and NAA38 KO cells
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD034104 | Pride
Hap1 cells Natc ko Lfq Shotgun Lc-ms/ms 
MetabolomicsSequential lipidomic, metabolomic, and proteomic analyses of serum, liver, and heart tissue specimens from peroxisomal biogenesis factor 11α knockout mice
Peroxisomes are versatile single membrane-enclosed cytoplasmic organelles, involved in reactive oxygen species (ROS) and lipid metabolism and diverse other metabolic processes. Peroxisomal disorders result from mutations in Pex genes-encoded proteins named peroxins (PEX proteins) and single peroxiso...
2022-02-02 | MTBLS1887 | MetaboLights
ProteomicsSUZ12 immunoprecipitation followed by protein indentification via mass spectrometry (SUZ12 IP-MS) in mESCs of SUZ12 WT, delta exon 4, KO, and KO rescues with SUZ12-L and SUZ12-S
Suz12 exon 4 encodes 23 amino acids (aa 129–152 in SUZ12-L) that partially overlap with the WD-binding domain 1 (WDB1, 110–145). We reasoned that exon 4 skipping might alter the structure of SUZ12 and, possibly, PRC2 composition. To explore this possibility, we generated ESCs that lack the Suz12 exo...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-18 | PXD046660 | Pride
Flag-tag Rescues Ko Ip Prc2 Interactions Mescs Escs Suz12 Polycomb 
ProteomicsShotgun analysis of proteins in NDUFA11 KO and WT HEK 293T cells.
The effect of the depletion of an ETC complex I protein component - NDUFA11 on the proteome in HEK 293T cells was studied. TMT-based relative quantification of protein levels were performed in NDUFA11 KO vs WT cells and in NDUFA11 KO vs WT cells that expressed an EGFP-MAPT (Tau protein) construct. I...
ORGANISM(S): Homo sapiens (Human) 
2023-07-03 | PXD038397 | Pride
Ndufa11 ko Egfp-mapt expression Etc complex i Hek 293t 
ProteomicsUBR4 KO analysis with TMT labeling
The impact of NatC and UBR4 on the human proteome (protein abundance). Analysis of HAP1 WT siCtr, HAP1 WT siUBR4, HAP1 NAA30 KO siCtr, and HAP1 NAA30 KO siUBR4 cells.
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD034410 | Pride
Hap1 ko cells Tmt Ubr4 Lc-ms/ms 
MetabolomicsGlobal untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo beta-lactamase, MBLAC1
The C. elegans gene swip-10 encodes an orphan metallo beta-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized...
2019-03-12 | MTBLS650 | MetaboLights
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