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ProteomicsECM-enriched mouse lung - TMT-based quantitative mass spectrometry analysis was performed on ECM-enriched preparation from normal murine lung, bleomycin-induced fibrotic lung, primary tumors and lymph node metastasis isolated from the KrasG12D/+p53-/- mouse model of lung adenocarcinoma. Three independent samples were processed and analyzed for each condition. This study identified ECM signatures of normal and diseased lung tissue.
TMT-based quantitative mass spectrometry analysis was performed on ECM-enriched preparation from normal murine lung, bleomycin-induced fibrotic lung, primary tumors and lymph node metastasis isolated from the KrasG12D/+p53-/- mouse model of lung adenocarcinoma. Three independent samples were process...
ORGANISM(S): Mus musculus (Mouse) 
2017-06-21 | PXD003517 | Pride
Extraceullar matrix 
UnknownAmelioration of rat adjuvant-induced arthritis by Met-RANTES.
Not available
S-EPMC1282452 | biostudies-literature
TranscriptomicsTranscription profiling by array of Mycobacterium tuberculosis to analyse the regulatory role of the HigA antitoxin
Data is also available from BuG@Sbase
ORGANISM(S): Mycobacterium tuberculosis 
2010-07-16 | E-BUGS-107 | biostudies-arrayexpress
TranscriptomicsThe Mycobacterium tuberculosis Clp Gene Regulator is Required for in vitro Reactivation from Hypoxia-induced Dormancy
The isogenic Mtb:ΔRv2745c mutant is significantly more sensitive normoxia conditions after a period of hypoxia, relative to wild-type Mtb, implicating a role for ClgR in response to reactivation, in vivo. Both hypoxia and reaeration treatment led to dysregulation of the σH regulon in the isogenic mu...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2014-12-12 | E-GEOD-64065 | biostudies-arrayexpress
TranscriptomicsStrategies for in vivo screening and mitigation of hepatotoxicity associated with antisense drugs
In this study we tested and modeled the hepatotoxic potential of locked nucleic acid-containing phosphorothioated antisense oligonucleotide (ASOs) gapmers designed to target human BACH1 and PAR-2 transcripts. Using RNA extracted from mouse livers we compared expression profiles of off-target (i.e. g...
ORGANISM(S): Mus musculus 
2017-08-02 | E-MTAB-5180 | biostudies-arrayexpress
ProteomicsGreenbug (Schizaphis graminum) Herbivory Effect on Switchgrass (Panicum virgatum) Proteome
Cereal aphids can successfully colonize and damage switchgrass (Panicum virgatum) plants. Among the aphids tested, greenbugs (Schizaphis graminum, GB) caused significant plant damage likely through a combination of aphid-salivary proteins that are injected into plants during feeding and a strong hos...
ORGANISM(S): Panicum virgatum (Switchgrass) 
2022-02-04 | PXD018547 | Pride
Greenbug Proteome Shotgun Switchgrass Label-free Lc-ms/ms 
ProteomicsGreenbug (Schizaphis graminum) Herbivory Effect on Switchgrass (Panicum virgatum) PhosphoProteomeGreenbug (Schizaphis graminum) Herbivory Effect on Switchgrass (Panicum virgatum) PhosphoProteome
Cereal aphids can successfully colonize and damage switchgrass (Panicum virgatum) plants. Among the aphids tested, greenbugs (Schizaphis graminum, GB) caused significant plant damage likely through a combination of aphid-salivary proteins that are injected into plants during feeding and a strong hos...
ORGANISM(S): Panicum virgatum (Switchgrass) 
2022-02-04 | PXD018546 | Pride
Greenbug Phosphoproteome Shotgun Switchgrass Label-free Lc-ms/ms 
ProteomicsAbsolute quantification of cohesin and its regulators in human cells
The organisation of mammalian genomes into loops and topologically associated domains (TADs) regulates gene expression. The formation and maintenance of loops and TADs depends on the protein complex cohesin, which also holds replicated sister chromatids together from S phase until mitosis. To unders...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012712 | Pride
Fluorescence-correlation spectroscopy Mass spectrometry Cell cycle Genome organization Cohesin Sister chromatid cohesion 
TranscriptomicsBCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancy
Mycobacterium tuberculosis is the causative agent of tuberculosis, a disease that affects one-third of the world’s population. The sole extant vaccine for tuberculosis is the live attenuated Mycobacterium bovis bacille Calmette-Guerin (BCG). We examined 13 representative BCG strains from around the ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2008-05-03 | E-GEOD-11315 | biostudies-arrayexpress
UnknownEndothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity
Not available
S-SCDT-EMBOR-2020-50767V1 | biostudies-other
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