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ProteomicsTear proteome revealed association of S100A family proteins and mesothelin with thrombosis in elderly patients with retinal vein occlusion
Tear samples collected from patients with central retinal vein occlusion (n=58) and group of healthy volunteers (n=30) were analyzed using a proteomic label-free absolute quantitative ap-proach. We found a large proportion (458 proteins with a frequency > 0.6) of tear proteome shared between healthy...
ORGANISM(S): Homo sapiens (Human) 
2022-12-13 | PXD037021 | Pride
Retinal vein occlusion  retinal hemostasis  s100a protein  mesothelin  inflammation 
ProteomicsSchizophrenia Proteome Research
Despite of multiple systematic studies of schizophrenia pathogenesis, reconstruction of the mechanism established on proteomics, metabolomics, and genome-wide significant loci is still a challenging task. We suggested that advanced data for quantitative proteomics, metabolomics, and genome-wide asso...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD035863 | Pride
Schizophrenia  data integration  pathway analysis  quantitative analysis  translational metabolomics 
ProteomicsBeta-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
Previous studies have demonstrated an importance of alpha-synuclein as a modulator of various mechanisms implicated in chemical neurotransmission but information about other two synuclein family members’ involvement in molecular processes taking place in presynaptic terminals is limited. Here we dem...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027786 | Pride
Dopamine Synapse Mptp toxicity Synuclein Transgenic mice Dopaminergic neurons Parkinson’s disease Vesicles Neurodegenerative disease Neurotransmitter vesicular uptake 
ProteomicsProteome profiling of myogenic differentiation of alveolar mucosa multipotent mesenchymal stromal cells revealed an unexpected deviation between 2D monolayer and 3D spheroid model cultures.
Recently, it has been proposed to employ three-dimensional cultivation of cell in spheroids that contributes more proper physiological conditions in matrix extracellular space architecture and cell morphology accompanied by appropriate intracellular biomechanical organization of cytoskeleton and ene...
ORGANISM(S): Homo sapiens (Human) 
2021-11-15 | PXD015410 | Pride
Myogenesis  monolayer culture  spheroid culture  cytoskeleton  mitochondria  autophagy 
ProteomicsUpdate on virtual-experimental 2DE approach in chromosome-centric human proteome project
In the boundaries of chromosome-centric Human Proteome Project c-HPP to obtain information about proteoforms coded by chromosome 18, several cell lines were analyzed. In our study we have been using proteoform separation by 2DE (sectional analysis) and semi-virtual 2DE with following shotgun mass-sp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-12 | MSV000086448 | MassIVE
ProteomicsChr18 Consortium MS-data for missing proteins mining
Despite direct or indirect efforts of proteomic community, the fraction of blind spots on the protein map is still significant. Almost 10% (?) of human master protein has no experimental validation up to now. Apparently, proteomics has reached the stage where all easy scores are achieved (?), and ev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-11 | MSV000086439 | MassIVE
ProteomicsExome-based proteogenomics of HEK-293 human cell line: coding genomic variants identified at the level of shotgun proteome
Genomic and proteomic data were integrated into the proteogenomic workflow to identify coding genomic variants of Human Embryonic Kidney 293 (HEK-293) standard cell line at the proteome level. Shotgun proteome data published by Geiger et al (2012) and obtained in this work for HEK-293 were searched ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080712 | MassIVE
ProteomicsAssessment of Serological Early Biomarker Candidates for Lung Adenocarcinoma by using Multiple Reaction Monitoring-Mass Spectrometry
Purpose: Serum markers that enable diagnosis in the early stage of lung cancer have not been discovered. We have developed a LC-MRM-MS assay for the identification of potential early marker proteins for lung adenocarcinoma. Experimental design: LC-MRM-MS assay was used for measuring the level of 35 ...
ORGANISM(S): Homo Sapiens 
2021-01-24 | PXD014683 | panorama
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