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TranscriptomicsExpression profiling, Lin-9 depletion array in D3 mES cells
Lin-9 was depleted in ES-D3 cells (ATCC CRL-1934) and the resulting expression profile changes mapped via microarrays
ORGANISM(S): Mus musculus 
2013-05-13 | E-MTAB-1490 | biostudies-arrayexpress
TranscriptomicsDeregulated Myc expression induces addiction to AMPK-related kinase 5
U2OS cells were infected with shRNA vector targeting Ark5 or control vector, selected on puromycin for 48hrs, seeded on 5cm dishes at 20% confluency and harvested in triplicate 48hrs later
ORGANISM(S): Homo sapiens 
2012-03-01 | E-MEXP-3543 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of skeletal myoblast differentiation and exposure to TNF-alpha or IGF1
Skeletal myocyte differentiation involves fusion of myoblasts to multinucleated myotubes. In vitro differentiation can be induced by serum withdrawal. The differentiation process is negatively regulated by pathological concentrations of TNF-alpha but can be positively regulated by IGF1. This study f...
ORGANISM(S): Mus musculus 
2015-04-05 | E-MTAB-3474 | biostudies-arrayexpress
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067224 | Pride
Limk Protac 
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067130 | Pride
Limk Protac 
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067272 | Pride
Limk Protac 
TranscriptomicsDeletion of DMD exon 52 in the pig results in fulminant muscular dystrophy
Duchenne muscular dystrophy (DMD) is caused by mutations in the X-linked dystrophin (DMD) gene. The absence of dystrophin protein leads to progressive muscle weakness and wasting, disability and death. To establish a tailored large animal model of DMD, we deleted DMD exon 52 in male pig cells by gen...
ORGANISM(S): Sus scrofa 
2013-08-06 | E-GEOD-44096 | biostudies-arrayexpress
UnknownThe genomic history of southeastern Europe.
Not available
S-EPMC6091220 | biostudies-literature
UnknownSBML Level 3: an extensible format for the exchange and reuse of biological models.
Not available
S-EPMC8411907 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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