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ProteomicsOxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B
The eukaryotic translation initiation factor 5B (eIF5B) is a homolog of the ancient IF2, a translation factor that facilitates initiator methionine-tRNAiMet (met-tRNAiMet) delivery to ribosomes in prokaryotes. IF2 evolved during early anaerobic cellular life and can be traced back to the last univer...
ORGANISM(S): Homo sapiens (Human) 
2018-01-03 | PXD006799 | Pride
Eif5b Oxygen Evolution Hypoxia Matrix Carbon metabolism If2 Translation 
ProteomicsSystemic remodeling of translation efficiencies on oxygen stimulus.
Protein concentrations evolve under greater evolutionary constraint than mRNA levels. In addition, translation efficiency of mRNA populations represents the chief determinant of basal protein concentrations. This raises a fundamental question as to how mRNA and protein levels are actively coordina...
ORGANISM(S): Homo sapiens (Human) 
2016-02-05 | PXD003037 | Pride
Cancer Silac Hypoxia Eif4e2 Translation Rna sequencing Eif4e 
ProteomicsAn oxygen-sensing network of RNA-binding proteins controls glycolysis via hypoxic translatome remodeling.
System-wide remodeling of protein synthesis is a keystone of cellular stress adaptation. Accumulating evidence suggests that changes in protein output (translatome) are controlled predominantly by translational mechanisms that restructure mRNA translation efficiencies (TEs), rather than simple fluct...
ORGANISM(S): Homo sapiens (Human) 
2020-07-02 | PXD011979 | Pride
Pcbp2 Pcbp1 Translation Hypoxia Ptbp1 Hnrnp a2/b1 Hur Hif Glycolysis Hif-2α 
ProteomicsSystemic remodeling of translation efficiencies on oxygen stimulus.
Protein concentrations evolve under greater evolutionary constraint than mRNA levels. In addition, translation efficiency of mRNA populations represents the chief determinant of basal protein concentrations. This raises a fundamental question as to how mRNA and protein levels are actively coordina...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079962 | MassIVE
ProteomicsTranslatome Hypoxia-Acidosis, TMT-pulse SILAC
Cells were grown in light (R0K0) SILAC media (AthenaES) for 7 days, they were then incubated in light media for 24 hours in respective condition (normoxia neutral (NN) pH: 7.4; hypoxia neutral (HN)1% O2, pH: 7.4; hypoxia acidosis (HA), 1% O2, pH=6) and pulsed with heavy (R10K8) SILAC media (AthenaES...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD015643 | Pride
U87-mg Tmt-pulse silac 
UnknownPediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome.
Not available
S-EPMC5138073 | biostudies-literature
UnknownTargeted Temperature Management After Pediatric Cardiac Arrest Due To Drowning: Outcomes and Complications.
Not available
S-EPMC5123789 | biostudies-literature
UnknownTherapeutic Hypothermia after In-Hospital Cardiac Arrest in Children.
Not available
S-EPMC5310766 | biostudies-literature
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