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ProteomicsAn optimized version of the Secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome
The secretome, the entirety of all soluble proteins either being secreted or proteolytically released by a cell, plays a key role in intercellular communication of multicellular organisms. Pathological alterations contribute to diseases such as hypertension, cancer, autoimmune disorders or neurodege...
ORGANISM(S): Homo sapiens (Human) 
2017-11-24 | PXD004555 | Pride
Glycocapture Glycoprotein Label-free quantification Specs 
ProteomicsSystematic substrate identification reveals a central role for the metalloprotease ADAM10 in axon targeting and synapse function
Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer’s disease amyloid precursor protein. ADAM10 is also req...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD003426 | Pride
Neurons Adam10 substrates Protease Bioorthogonal chemistry 
ProteomicsSPPL3 cleavage of glycosyltransferases regulates their activity
The GxGD intramembrane-cleaving aspartylprotease signal peptide peptidase-like 3 (SPPL3) is a Golgi-resident, multi-pass membrane protein that is highly conserved among multicellular eukaryotes pointing to a pivotal physiological function in the Golgi network. Recently, the key branching enzyme N-ac...
ORGANISM(S): Homo sapiens (Human) 
2015-05-08 | PXD001672 | Pride
Substrates Protease Specs Sppl3 
OtherLabel-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects beta-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo
Data from ProteomeXchange, PXD ID: PXD001514. File: CSF124WT_50cm_TR1.mzml. Published as part of Mol Cell Proteomics. 2015 Oct;14(10):2550-63 . From the Abstract: {{i}} ... We demonstrate that the CSF proteome of individual mice can be analyzed in a quantitative manner to a depth of several hundred...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310025075 | GPMDB
Resource Reanalysis 
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