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ProteomicsSystematic substrate identification reveals a central role for the metalloprotease ADAM10 in axon targeting and synapse function
Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer’s disease amyloid precursor protein. ADAM10 is also req...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD003426 | Pride
Neurons Adam10 substrates Protease Bioorthogonal chemistry 
ProteomicsSPPL3 cleavage of glycosyltransferases regulates their activity
The GxGD intramembrane-cleaving aspartylprotease signal peptide peptidase-like 3 (SPPL3) is a Golgi-resident, multi-pass membrane protein that is highly conserved among multicellular eukaryotes pointing to a pivotal physiological function in the Golgi network. Recently, the key branching enzyme N-ac...
ORGANISM(S): Homo sapiens (Human) 
2015-05-08 | PXD001672 | Pride
Substrates Protease Specs Sppl3 
OtherLabel-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects beta-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo
Data from ProteomeXchange, PXD ID: PXD001514. File: CSF124WT_50cm_TR1.mzml. Published as part of Mol Cell Proteomics. 2015 Oct;14(10):2550-63 . From the Abstract: {{i}} ... We demonstrate that the CSF proteome of individual mice can be analyzed in a quantitative manner to a depth of several hundred...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310025075 | GPMDB
Resource Reanalysis 
UnknownConformation space of a heterodimeric ABC exporter under turnover conditions.
Not available
S-EPMC7612745 | biostudies-literature
ProteomicsNeuronal differentiation of LUHMES cells is accompanied by substantial changes of the proteome
To study mechanisms of neurodegenerative diseases, neuronal cell lines are important model systems and are often differentiated into postmitotic neuron-like cells to resemble more closely primary neurons obtained from brains. One such cell line is the Lund Human Mesencephalic (LUHMES) cell line whic...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-09-24 | PXD020044 | Pride
Luhmes cells Dopaminergic neuron Murine midbrain neurons Parkinson’s disease 
ProteomicsBACE1 KO mouse CSF LC-MSMS - Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo
Analysis of murine cerebrospinal fluid (CSF) by quantitative mass spectrometry is challenging due to low CSF volume, low total protein concentration and the presence of highly abundant proteins such as albumin. We demonstrate that the CSF proteome of individual mice can be analyzed in a quantitative...
ORGANISM(S): Mus musculus (Mouse) 
2015-10-12 | PXD001514 | Pride
Mouse csf Csf Label-free quantification 
UnknownIntensive grazing alters the diversity, composition and structure of plant-pollinator interaction networks in Central European grasslands.
Not available
S-EPMC8916670 | biostudies-literature
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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