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ProteomicsIdentifying host factors associated with DNA replicated during virus infection
Viral DNA genomes replicating in cells encounter a myriad of host factors that facilitate or hinder viral replication. Viral proteins expressed early during infection modulate host factors interacting with viral genomes, recruiting proteins to promote viral replication, and limiting access to antivi...
ORGANISM(S): Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) Homo sapiens (Human) Vaccinia virus WR Herpesvirales 
2017-10-04 | PXD007741 | Pride
Virus infection / dna replication / dna repair / intrinsic defense 
ProteomicsThe Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly
Paramyxoviruses are negative sense single-stranded RNA viruses that comprise many important human and animal pathogens, including human parainfluenza viruses. These viruses bud from the plasma membrane of infected cells after the viral ribonucleoprotein complex (vRNP) is transported from the cytopla...
ORGANISM(S): Homo sapiens (Human) Murine respirovirus 
2020-08-06 | PXD019637 | Pride
Rab11a Sendai virus cantell A549 cells 
ProteomicsQuantitative Live Cell Imaging Reveals Differential Manipulation of Rab11A Transport Pathways by Influenza virus and RSV
Assembly of infectious influenza A viruses (IAV) is a complex process involving transport from the nucleus to the plasma membrane. Rab11A containing recycling endosomes have been identified as a platform for intracellular transport of viral RNA (vRNA). Using high spatiotemporal resolution light-shee...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/California/07/2009(H1N1)) 
2020-01-14 | PXD016331 | Pride
Live-cell imaging Rab11a Influenza virus Vesicle tracking Light-sheet microscopy Assembly Rna Microtubules Endosomes Fluorescence microscopy Viral rna Motor transport 
ProteomicsIdentification of SLFN5 as an intrinsic inhibitor of viral transcription antagonized by the herpes simplex virus ubiquitin ligase ICP0
Intrinsic antiviral host factors are proteins that can confer cellular defense by limiting virus replication. Viruses hijack ubiquitin machinery to modify the cellular proteome to subvert these host defenses. The herpes simplex virus 1 (HSV-1) expresses ICP0, which functions as an E3 ubiquitin ligas...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) Human alphaherpesvirus 1 
2020-09-14 | PXD018773 | Pride
Dicp0 Herpes simplex virus Slfn5 Ipond Hsv-1 Ubiquitin Icp0 
ProteomicsAdenovirus remodeling of the host proteome and of host factors associating with viral genomes
Viral infections are associated with extensive remodeling of the cellular proteome. Viruses encode gene products that manipulate host proteins to redirect cellular processes or subvert antiviral immune responses. One way in which host antiviral proteins antagonize viral infection is by associating w...
ORGANISM(S): Viruses Homo sapiens (Human) 
2021-08-11 | PXD025339 | Pride
Intrinsic defense Dna virus Ipond Virus infection Adenovirus 
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