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TranscriptomicsTranscription profiling of male and female embryo chicken brain, time series
The differnece in genexpression between male and female embryo chicken brain. The aim of the study was to look at the diffirence in genexpression between chicken male and female at 4 different stages. For each day 4 arrays were conducted. Ed4,6, 8 and 10. For ed 10 the experiment was both conducted ...
ORGANISM(S): Gallus gallus 
2005-06-30 | E-MEXP-266 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse control 25-dpc embryos from control vs. valproic acid (VPA) treated dams and control P19 mouse EC cells vs 1 mM sodium valproate for 24 h
Valproic acid (VPA) is a potent inducer of neural tube defects (NTDs), but its mechanism of teratogenicity is not known. To study the transcriptional response of VPA during the susceptible period, i.e. when VPA is likely to exert most of its teratogenic effect, RNA was extracted from 8.25-dpc embryo...
ORGANISM(S): Mus musculus 
2004-08-01 | E-MEXP-45 | biostudies-arrayexpress
ProteomicsHuman temporal neocortex brain LC-MS
We used label-free shotgun mass spectrometry to analyze temporal neocortex samples from AD brain, other neurological disorders and non-demented controls, in order to identify additional proteins thatare altered in AD. The mass spectrometry results were then verified by antibody suspension bead arra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-26 | MSV000081016 | MassIVE
ProteomicsSystematic Analysis of the Cerebrospinal Fluid Proteome of Fibromyalgia patients
Fibromyalgia (FM) is a syndrome characterized by widespread muscular pain, fatigue and functional symptoms, which is known to be difficult to diagnose as the various symptoms overlap with many other conditions. Currently, there are no biomarkers for FM, and the diagnosis is made subjectively by the ...
ORGANISM(S): Homo sapiens (Human) 
2018-04-25 | PXD008076 | Pride
Fibromyalgia Lc-ms Csf Biomarker 
MetabolomicsAlterations in the tyrosine and phenylalanine pathways revealed by biochemical profiling in cerebrospinal fluid of Huntington’s disease subjects
Huntington's disease (HD) is a severe neurological disease leading to psychiatric symptoms, motor impairment and cognitive decline. The disease is caused by a CAG expansion in the huntingtin (HTT) gene, but how this translates into the clinical phenotype of HD remains elusive. Using liquid chromatog...
2019-06-21 | MTBLS749 | MetaboLights
ProteomicsHuman temporal neocortex brain LC-MS
We used label-free shotgun mass spectrometry to analyze temporal neocortex samples from AD brain, other neurological disorders and non-demented controls, in order to identify additional proteins thatare altered in AD. The mass spectrometry results were then verified by antibody suspension bead arra...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD004499 | Pride
Alzheimer’s disease  mass spectrometry  antibodies Immobilized/chemistry  extracellular vesicles  exosomes  exocytosis  endocytosis. 
ProteomicsProteomics on colorectal cancer MCTS upon OXPHOS inhibition
Previous high throughput gene expression profiling combined with a HCT116 colon cancer tumor spheroid-based drug-screening assay identified context-dependent treatment responses to OXPHOS inhibitors resulting in a shunting towards the mevalonate pathway. To complement these findings with a character...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD016495 | Pride
Colon cancer Oxphos Proteomics Spheroids Energy metabolism 
MetabolomicsDisease phenotype prediction in multiple sclerosis

Progressive multiple sclerosis (PMS) is currently diagnosed retrospectively. Here, we work towards a set of biomarkers that could assist in early diagnosis of PMS. A selection of cerebrospinal fluid metabolites (n=15) was shown to differentiate between PMS and its preceding phenotype in an indepe...

2023-05-31 | MTBLS1464 | MetaboLights
MetabolomicsMass spectrometry based metabolomics for in vitro systems pharmacology: Pitfalls, challenges, and computational solutions

INTRODUCTION: Mass spectrometry based metabolomics has become a promising complement and alternative to transcriptomics and proteomics in many fields including in vitro systems pharmacology. Despite several merits, metabolomics based on liquid chromatography mass spectrometry (LC...

2017-08-23 | MTBLS401 | MetaboLights
ProteomicsInhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
We compared the effects of mPGES-1 inhibitor Compound III (CIII) with the cyclooxygenase (COX)-2 inhibitor NS-398 on protein and lipid profiles in interleukin (IL)-1β induced A549 lung cancer cells using mass spectrometry. Inhibition of mPGES-1 decreased PGE2 production and increased PGF2α and throm...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD013490 | Pride
Inflammation A549 Cancer Mpges-1 Lc-ms/ms 
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