Sort   by:  
 Page size 
ProteomicsProteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP - SPP datasets
Nucleotide triphosphates (NTPs) regulate numerous biochemical processes in cells as (co-)substrates, allosteric modulators, biosynthetic precursors, and signaling molecules1-3. Apart from its roles as energy source fueling cellular biochemistry, adenosine triphosphate (ATP), the most abundant NTP in...
ORGANISM(S): Homo sapiens (Human) 
2019-03-11 | PXD012356 | Pride
Atp Jurkat Spp 
ProteomicsProteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP - TPP datasets
Nucleotide triphosphates (NTPs) regulate numerous biochemical processes in cells as (co-)substrates, allosteric modulators, biosynthetic precursors, and signaling molecules1-3. Apart from its roles as energy source fueling cellular biochemistry, adenosine triphosphate (ATP), the most abundant NTP in...
ORGANISM(S): Homo sapiens (Human) 
2019-03-11 | PXD012423 | Pride
Atp Jurkat Tpp 
ProteomicsProteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP - effect of Mg dataset
Nucleotide triphosphates (NTPs) regulate numerous biochemical processes in cells as (co-)substrates, allosteric modulators, biosynthetic precursors, and signaling molecules1-3. Apart from its roles as energy source fueling cellular biochemistry, adenosine triphosphate (ATP), the most abundant NTP in...
ORGANISM(S): Homo sapiens (Human) 
2019-03-11 | PXD012745 | Pride
Atp Jurkat Spp 
ProteomicsRobust ligand-protein interaction inference reveals off-targets of epigenetic drugs
Detecting target engagement is a major challenge in drug discovery. To this end, thermal proteome profiling (TPP) offers unbiased assessment of system-wide ligand-protein interactions. However, its most sensitive assay format lacks statistical methods with false discovery rate-control. Here, we pres...
ORGANISM(S): Homo sapiens (Human) 
2020-10-29 | PXD016640 | Pride
Tpp Epigenetic drugs 
ProteomicsTissue Thermal Proteome Profiling
We introduce tissue Thermal Proteome Profiling (tissue-TPP) which enables the discovery of drug targets and off-targets as well as measurements of target occupancy in tissue samples derived from dosed animals. Here we report the first proteome-wide thermal stability map of tissues and organ-specific...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2020-01-07 | PXD016277 | Pride
Human Rat Tpp 
ProteomicsTissue Thermal Proteome Profiling
We introduce tissue Thermal Proteome Profiling (tissue-TPP) which enables the discovery of drug targets and off-targets as well as measurements of target occupancy in tissue samples derived from dosed animals. Here we report the first proteome-wide thermal stability map of tissues and organ-specific...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-07 | PXD015458 | Pride
Tpp Mouse Liver 
ProteomicsTissue Thermal Proteome Profiling
We introduce tissue Thermal Proteome Profiling (tissue-TPP) which enables the discovery of drug targets and off-targets as well as measurements of target occupancy in tissue samples derived from dosed animals. Here we report the first proteome-wide thermal stability map of tissues and organ-specific...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-07 | PXD015427 | Pride
Tpp Tissues Rat Cell line 
ProteomicsTissue Thermal Proteome Profiling
We introduce tissue Thermal Proteome Profiling (tissue-TPP) which enables the discovery of drug targets and off-targets as well as measurements of target occupancy in tissue samples derived from dosed animals. Here we report the first proteome-wide thermal stability map of tissues and organ-specific...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD015373 | Pride
Tpp Human Blood 
ProteomicsTissue Thermal Proteome Profiling
We introduce tissue Thermal Proteome Profiling (tissue-TPP) which enables the discovery of drug targets and off-targets as well as measurements of target occupancy in tissue samples derived from dosed animals. Here we report the first proteome-wide thermal stability map of tissues and organ-specific...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD015397 | Pride
Tpp Human Hl60 Hepg2 Thp1 
Sort   by:  
 Page size