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TranscriptomicsComparative genomic hybridization of Leishmania mexicana wild type and glucose transporter (lmgt) knock-out strains show genomic adaptation
Genomic adaptation following glucose transporter knockout in leishmania mexicana
ORGANISM(S): Leishmania mexicana 
2008-12-01 | E-MEXP-1858 | biostudies-arrayexpress
TranscriptomicsTranscript abundance comparison between BALB/c ears inoculated with Leishmania mexicana and Leishmania mexicana plus promastigote secretory gel (PSG)
To determine the modulation of gene expression of Leishmania mexicana(M379)-inoculated BALB/c ears in the presence of promastigote secretory gel (PSG) A genome-wide transcriptional analysis was performed by comparing the gene expression profiles of Leishmania mexicana- inoculated BALB/c ears and L...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-52101 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Leishmania mexicana promastigotes, axenic amastigotes and intracellular amastigotes
We used Illumina sequencing of poly-A selected RNA of Leishmania mexicana (WHO strain MNYC/BZ/62/M379) culture-adapted promastigotes (PRO), axenic amastigotes (AXA) and intracellular amastigotes (AMA) in mouse bone marrow derived macrophages (BMDM), 24h after infection, to map 5' and 3' ends of Leis...
ORGANISM(S): Leishmania mexicana 
2015-09-11 | E-MTAB-3312 | biostudies-arrayexpress
ProteomicsQueuosine-modified tRNA influences differentiation of Leishmania mexicana by codon bias translation
Using quantitative proteomics, we aim to compare the total proteome of L. mexicana wild (WT), knock-out (KO) and addback. The protein profile of all three will be related at five separate time points of life cycle differentiation. The objective is to elucidate the impact of Q-tRNA depletion on cellu...
ORGANISM(S): Leishmania mexicana 
2026-06-03 | PXD061534 | Pride
Leishmania mexicana Proteomics Queuosine Differentiation Timstof Translation 
ProteomicsUnique Leishmania mexicana clones secrete populations of extracellular vesicles with unique protein profile and variable infectious capability
The study of extracellular vesicles has become an incredibly important field of study, but the inherent heterogeneity of these vesicles continues to make their study challenging. The genetic variability and well-documented protocols for the growth and vesicle isolation from Leishmania parasites prov...
ORGANISM(S): Leishmania mexicana 
2025-05-07 | PXD058429 | Pride
Exosomes Proteomics Extracellular vesicles Infectious disease Leismania mexicana Clonal cultures 
ProteomicsTranscriptome-wide identification of coding and noncoding RNA-binding proteins defines the extended RNA interactome of Leishmania mexicana
Non-poly(A) RNA molecules including noncoding RNAs (ncRNAs) comprise the major portion of the total transcribed molecules in the cell. In addition to the mRNAs the ncRNAs also function as ribonucleoprotein particles (RNPs) and carry out biological functions including synthesis of new proteins, RNA p...
ORGANISM(S): Leishmania mexicana MHOM/GT/2001/U1103 
2022-01-14 | PXD028092 | Pride
Leishmania Rna-binding proteins 
MetabolomicsMining for natural product antileishmanials in a fungal extract library
Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the World’s poorest, however vaccines are absent and drug therapy limited. Recently, public-private partnerships have developed to identify new modes ...
2021-02-12 | MTBLS868 | MetaboLights
ProteomicsThree types of Leishmania mexicana amastigotes: proteome comparison by quantitative proteomic analysis
Leishmania is the unicellular parasite transmitted by phlebotomine sand fly bite. It exists in two different forms; extracellular promastigotes, occurring in the gut of sand flies, and intracellular, round-shaped amastigotes residing mainly in vertebrate macrophages. As amastigotes originating from ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD036664 | Pride
Amastigotes L. mexicana 
ProteomicsGlobal phosphoproteome of Leishmania mexicana developmental stages
Using a combination of phosphoproteome enrichment and tandem mass tag (TMT) labelling-based quantitative proteomic mass spectrometry (MS), we robustly identified and quantified 1,833 phosphorylated proteins across three life cycle stages of Leishmania mexicana (L. mexicana) parasite. Protein kinase ...
ORGANISM(S): Leishmania mexicana MHOM/GT/2001/U1103 
2023-10-04 | PXD043002 | Pride
Phosphoproteome Tmt labelling Leishmania 
ProteomicsIntralysosomal pathogens differentially influence the proteolytic potential of their niche
Avoiding lysosomal degradation is vital to the success of intracellular pathogens. The Gram-negative bacterium C. burnetii and protozoan parasites of the Leishmania genus share the unique ability to replicate within a host phagolysosomal compartment, though the exact mechanisms utilised to withstand...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD063745 | Pride
Leishmania mexicana Coinfection Coxiella burnetii Cathepsin b Cathepsin d 
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