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ProteomicsDifferential retinal protein expression in primary and secondary retinal ganglion cell degeneration identified by integrated SWATH and target-based proteomics
To investigate the retinal proteins associated with primary and secondary retinal ganglion cell (RGC) degeneration and explore their molecular pathways, SWATH label-free and target-based mass spectrometry was employed to identify the proteomes in various retinal locations in response to localized op...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-07 | PXD026783 | Pride
Ganglion cell Mass spectrometry Neurodegeneration Optic nerve Protein 
ProteomicsDeep Quantitative Spectral Library of Normal and Myopic Mice Retinas: Proteomics Dataset from SWATH and DIA-NN
The retina plays a crucial role in processing and decoding visual information, both in normal development and during myopia progression. Recent advancements have introduced a library-independent approach for data-independent acquisition (DIA) analyses. This study demonstrates deep proteome identific...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-19 | PXD046983 | Pride
Retina Dia-nn Myopia Mice Swath-ms 
ProteomicsComprehensive retinal characterization of myopic guinea pigs after PI3K/AKT inhibition via data-independent acquisition on an Orbitrap Exploris 480 mass spectrometer.
Myopia progression is driven by abnormal signaling pathways, particularly the PI3K/AKT pathway. Using a lens-induced myopia model in guinea pigs, we administered the PI3K/AKT inhibitor LY294002 via intravitreal injection and performed quantitative proteomic analysis with data-independent acquisition...
ORGANISM(S): Cavia 
2026-03-23 | PXD074201 | Pride
ProteomicsValidation of potential growth-related proteins in chick vitreous during emmetropization using targeted-based proteomics (MRMHR)
The relatively new high-resolution MRM (MRMHR) approach with the Triple-TOF MS running under nanoflow was adopted in this study to solidify further the findings of SWATH-MS results of differentially expressed proteins found across the time points in the chick vitreous for the benefit of low peptide ...
ORGANISM(S): Gallus gallus (Chicken) 
2024-09-25 | PXD056184 | Pride
Vitreous Swath-ms Mrmhr 
ProteomicsData for Cross-platform Construction of Comprehensive Proteomic Database for Human Corneal Epithelial Cell
Comprenhensive proteomic analysis of HCEC using Trapped Ion Mobility Spectrometry Time-of-Flight Pro2, Orbitrap Fusion Lumos and ZenoTrap Time-of-Flight 7600 Mass Spectrometer
ORGANISM(S): Homo sapiens (Human) 
2025-03-24 | PXD059451 | Pride
Timstof Proteome Orbitrap Zenotof Human corneal epithelial cell 
ProteomicsProteomic profiling of human corneal epithelial cells under hyperosmotic stress
This project compared the proteomic change between human corneal epithelial cells cultured under hyperosmotic and isosmotic condition. This aimed to reveal differentially expressed proteins that was associated with osmoregulation in human corneal epithelial cells.
ORGANISM(S): Homo Sapiens (human) 
PXD054330 | JPOST Repository
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