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ProteomicsPhosphorylation of PABPN1 during mitosis protects mRNA from hyperadenylation and maintains transcriptome stability.
Polyadenylation controls mRNA biogenesis, nuclear export, translation, and decay. These processes are interdependent and coordinately regulated by several poly(A)-binding proteins (PABPs). How PABPs are functionally regulated to control RNA fate is not fully understood. Here, we show that human PABP...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD047110 | Pride
3′ end processing factors  polyadenylation Pabpn1 Rna stability Cell cycle Long-read sequencing 
ProteomicsA complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts.
Junctions between the ER and the plasma membrane (ER/PM junctions) are implicated in calcium homeostasis, non-vesicular lipid transfer and other cellular functions. Two ER proteins that function both as membrane tethers to the PM via a polybasic motif in their C-terminus and as phospholipid transpor...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD047112 | Pride
Syncam Lipid transfer Subsurface cisterns Smp domain C2cd2l 
ProteomicsThe C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent potentially lethal monogenic disorder. Mutations in the PKD1 gene, which encodes polycystin-1 (PC1), account for approximately 78% of cases. PC1 is a large 462-kDa protein that undergoes cleavage in its N and C-terminal domai...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-17 | PXD040210 | Pride
Metabolism Polycystin-1 (pc1) C-terminal tail (ctt) Autosomal dominant polycystic kidney disease (adpkd) Nicotinamide nucleotide transhydrogenase (nnt) Mitochondria 
ProteomicsCitrullination of glucokinase is linked to autoimmune diabetes
Inflammation, including reactive oxygen species and inflammatory cytokines in tissues amplify various post-translational modifications (PTMs) of self-proteins. A number of PTMs have been identified as autoimmune biomarkers in the initiation and progression of Type 1 diabetes (T1D). In this study, ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-17 | PXD028825 | Pride
Post-translational modifications Type 1 diabetes Glucokinase 
ProteomicsMapping the proteome of the synaptic cleft through peroxidase-based reporter protein SynCAM1-HRP
Synapses are the brain’s functional units connecting neurons into circuits that underlie memory and behavior. These specialized neuronal junctions are heterogenic in function and molecular composition, reflecting diverse health and disease states. Progress over the past years has shown that trans-sy...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-12-04 | PXD011312 | Pride
Lc ms/ms Synaptomics Synaptic cleft Synapse composition Syncam1 Proximity labeling Proteomics 
ProteomicsCEGS Proteomics - A multiregional proteomic survey of the postnatal human brain
Here we exploit label-free quantitative tandem mass-spectrometry proteomics to create the first in-depth quantitative proteomic survey of regions of the postnatal human brain. We adopted a dual approach to analysing these human brain samples similar to that of a recent high-quality study of the mou...
ORGANISM(S): Homo sapiens (Human) 
2018-01-09 | PXD005445 | Pride
Human brain Regions Post natal development 
ProteomicsmPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model
Stressful events are a leading factor in development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors results in synaptic dysfunction and loss. Learned helplessness is a behavioral paradigm that measures effec...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-20 | PXD073765 | Pride
Mpfc Acetylcholine Major depressive disorder Stress models Learned helplessness Muscarinic receptors Proteomics 
ProteomicsAutoinhibition of Trio guanine nucleotide exchange factor activity for Rac1 by its spectrin repeats is disrupted by neurodevelopmental disorder-related genetic variants.
Function-damaging variants in the TRIO gene are enriched in individuals with neurodevelopmental disorders (NDDs). TRIO encodes a cytoskeletal regulatory protein with three catalytic domains – two guanine exchange factor (GEF) domains, GEF1 and GEF2, and a kinase domain, as well as several accessory ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-13 | PXD034393 | Pride
Limited proteolysis Neurodevelopment disorders Trio gene Crosslinking 
ProteomicsThe proteomic landscape of parkin-deficient and parkin-overexpressing rat nucleus accumbens: an insight into the role of parkin in methamphetamine use disorder
In recent years, methamphetamine (METH) misuse in the US has been rapidly increasing, and there is no FDA-approved pharmacotherapy for METH use disorder (MUD). We previously determined that ubiquitin-protein ligase parkin is involved in the regulation of METH addictive behaviors in rat models of MUD...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-04 | PXD065059 | Pride
Parkin  proteome  nucleus accumbens  mitochondria  methamphetamine 
ProteomicsCellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Tissue mechanical homeostasis, the concept that cells sense mechanical properties and alter rates of ECM synthesis, assembly and degradation, is of broad interest in biology and medicine, but there is little direct support or insight into mechanisms. Tissue mechanical properties such as elasticity a...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD041630 | Pride
Focal adhesions Stiffness-sensing Mechanical homeostasis Extra-cellular matrix Talin 
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