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ProteomicsMCF7 xenografts with 5-FU in vivo ITDR-CETSA
MCF7 xenograft-bearing mice were treated intravenously for 22h with either vehicle or different 5-FU doses (10, 50, 100, and 150 mg/kg). Each xenograft was cut in similar-sized pieces and assembled into an ITDRCETSA scheme with 2 different heating temperatures (37ºC, 52ºC) and 3 xenograft pieces for...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026470 | JPOST Repository
ProteomicsIMPRINTS-CETSA, 5-FU in parental and 5-FU-resistant HCT15 cells
Parental and 5-fluorouracil (5-FU)-resistant HCT15 cells were treated with 5-FU or vehicle for 12h and assembled into an IMPRINTS-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC, 54ºC, and 57ºC) with each set of samples heated at one temperature included in the same isobar...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026472 | JPOST Repository
ProteomicsIMPRINTS-CETSA, FUDR and FUR in MCF7 cells, 2h and 12h incubation
MCF7 cells were treated with floxuridine (FUDR), fluorouridine (FUR), or vehicle and assembled into an IMPRINTS-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC, 54ºC, and 57ºC) with each set of samples heated at one temperature included in the same isobaric TMT10 set and m...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026471 | JPOST Repository
GenomicsIL-10 production and metabolic regulation in macrophages are linked by a TLR-driven CREB-mediated mechanism
IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections macrophages are an important source of IL-10, however the molecular mechanism underpinning production of IL-10 by these cells is poorly characterized. Here, bone ...
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-64844 | biostudies-arrayexpress
ProteomicsDomain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating its tumor suppressive functions, and by conferring aberrant pro-carcinogenic activities. We report here that mis-sense mutants in the p53 DNA-binding domain (DBD) and the transactivation domain (TAD) unexpectedly activate...
ORGANISM(S): Homo Sapiens (human) 
2023-02-17 | PXD031725 | JPOST Repository
UnknownResults of the two incidence screenings in the National Lung Screening Trial.
Not available
S-EPMC4307922 | biostudies-literature
UnknownIdentification of common variants associated with human hippocampal and intracranial volumes.
Not available
S-EPMC3635491 | biostudies-literature
UnknownPharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis.
Not available
S-EPMC5763501 | biostudies-literature
UnknownReduced lung-cancer mortality with low-dose computed tomographic screening.
Not available
S-EPMC4356534 | biostudies-literature
UnknownHigher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC11872607 | biostudies-literature
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