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TranscriptomicsDistinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Rheb, a ras-like small GTPase conserved from human to yeast, controls Tor kinase and plays a central role in regulation of cell growth depending on extracellular conditions. Fission yeast Rheb regulates amino acid uptake as well as response to nitrogen starvation. In this study we generated two muta...
ORGANISM(S): Schizosaccharomyces pombe 
2009-09-28 | E-GEOD-14626 | biostudies-arrayexpress
ProteomicsThe large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila
The facultative intracellular bacterium Legionella pneumophila employs the Icm/Dot type IV secretion system (T4SS) to replicate in a unique membrane-bound compartment, the Legionella-containing vacuole (LCV). The ER-resident large fusion GTPase Sey1/atlastin-3 promotes remodeling and expansion of LC...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2023-06-07 | PXD038200 | Pride
Large fusion gtpase Legionella pneumophila Atlastin Lipid droplet Legionnaires’ disease Host-pathogen interaction Pathogen vacuole Fatty acid transport Amoeba Dictyostelium discoideum 
UnknownA large Rab GTPase family in a small GTPase world.
Not available
S-EPMC5331893 | biostudies-literature
UnknownDual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation.
Not available
S-EPMC6925385 | biostudies-literature
UnknownMembrane fusion by the GTPase atlastin requires a conserved C-terminal cytoplasmic tail and dimerization through the middle domain.
Not available
S-EPMC3131361 | biostudies-literature
ProteomicsCEP19-RABL2 GTPase complex in ciliary transport
The mechanisms of how highly conserved intraflagellar transport (IFT) protein complexes direct ciliary entry remain unknown. Exploring human ciliopathy genes, including monogenic obesity syndrome genes, has been a rich source of critical ciliary mechanisms. Using AP-MS purification of interactors of...
ORGANISM(S): Homo sapiens (Human) 
2017-06-21 | PXD006757 | Pride
Metabolic syndrome Gtpase Cep19-rabl2b complex Microtubules Bardet-biedl syndrome Proteomics Genetics" Obesity Ciliopathy Human genetics Centrosome Intraflagellar transport Centriole Cilia 
UnknownA large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.
Not available
S-EPMC5013727 | biostudies-literature
MetabolomicsTargeted metabolomic profiling of retinas from WT and Rho-Cre/Mfn1flx/flx/Mfn2flx/flx mice
Mitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these structures include elongated mitochondria in the inner segments and a distinct, large, circular mitochondrion in each ...
2026-03-12 | MTBLS12512 | MetaboLights
UnknownThe large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila.
Not available
S-EPMC10259473 | biostudies-literature
GenomicsColorectal cancer organoids expressing BRAF (fusion) genes
Fusion genes may be oncogenic drivers and potential targets for personalized therapies in a variety of cancer types. The BRAF gene is frequently involved in oncogenic fusions, with fusion frequencies of 0.2-3% throughout different cancers. BRAF can be fused to a wide variety of genes, however, BRAF ...
EGAS00001003558 | EGA
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