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ProteomicsCubilin is a Novel Target Antigen in Anti-Brush Border Antibody Disease
Autoimmune diseases that affect the kidney proximal tubule (PT) cause proteinuria and are implicated in the pathogenesis of kidney failure. Previous evidence demonstrated that circulating anti-brush border antibodies (ABBA) target megalin (LRP2) but whether other components of the PT drive autoimmun...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD030159 | Pride
Human Dia Kidney Lc-ms 
ProteomicsComparative proteomic analysis of Plasmodium falciparum parasites with and without the prenol kinase-encoding gene (knockout parasites)
The methylerythritol 4-phosphate (MEP) pathway, essential for producing isoprenoids in Plasmodium parasites. The key isoprenoids produced by the MEP pathway are farnesyl and geranylgeranyl pyrophosphates (FPP and GGPP), vital for protein isoprenylation, ubiquinone, and dolichol biosynthesis. In vitr...
ORGANISM(S): Plasmodium falciparum NF54 
2026-09-16 | PXD059094 | Pride
Geranylgeraniol Knockout Malaria Isoprenoid metabolism Farnesol Plasmodium falciparum Prenol kinase 
MetabolomicsGNPS - Dataset Creation from GNPS Molcular Networking - 89895d4507c84596a6a01685bfd8acd4
Molecular Networking of fungal culture extracts from T. erinacei analyzed by LC-MS in positive ion mode
ORGANISM(S): Trichophyton Erinacei (ncbitaxon:523106) 
2021-04-29 | MSV000087335 | GNPS
TranscriptomicsNuclear tRNA sequestering slows aging by a mechanism similar to dietary restriction
Dietary restriction (DR) is the best-characterized intervention for slowing aging, and reduced signaling through the target of rapamycin (TOR) kinase is believed to be one of the key mechanisms by which DR extends life span in organisms from yeast to mammals. Here we describe a role for nuclear seq...
ORGANISM(S): Saccharomyces cerevisiae 
2015-02-03 | E-GEOD-37241 | biostudies-arrayexpress
ProteomicsCharacterization of signaling pathways associated with pancreatic β-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice
Obesity-linked type 2 diabetes (T2D) is a major health problem of global epidemic proportions. The onset of T2D is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to o...
ORGANISM(S): Mus Musculus 
2020-05-18 | PXD016392 | panorama
ProteomicsA Fbxo48 inhibitor prevents pAMPKa degradation and ameliorates insulin resistance
Beas-2b cells treated with vehicle or BC1618 compound, which targets the ubiquitin E3 ligase for targeted degradation of pAMPKa protein. Cell lysate was subjected to mass spectrometry for phosphoproteomics to uncover alterations in the phosphoproteome.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-20 | MSV000086334 | MassIVE
UnknownLipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.
Not available
S-EPMC8822604 | biostudies-literature
UnknownOutcome after reduced chemotherapy for intermediate-risk neuroblastoma.
Not available
S-EPMC2993160 | biostudies-literature
UnknownMethotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial.
Not available
S-EPMC4486345 | biostudies-literature
UnknownEfficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
Not available
S-EPMC5731244 | biostudies-literature
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