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UnknownA selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation.
Not available
S-EPMC6030159 | biostudies-literature
UnknownMYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner.
Not available
S-EPMC9980915 | biostudies-literature
UnknownClinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention.
Not available
S-EPMC5824290 | biostudies-literature
ProteomicsThe mitochondrial single-stranded DNA binding protein directs RNA primer formation for mtDNA replication
Single-stranded DNA (ssDNA) binding proteins protect regions of ssDNA formed during processes such as DNA replication and repair. We here devise a genetic screen and identify the mitochondrial ssDNA-binding protein (mtSSB) as a key regulator of mtDNA levels. In mitochondria, RNA synthesis from the l...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-19 | PXD021799 | Pride
Mtdna Tmt Replication Mtssb 
ProteomicsTranscriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals
Abstract Dysfunction of the oxidative phosphorylation (OXPHOS) system is a major cause of human disease and the cellular consequences are highly complex. Here, we present comparative analyses of mitochondrial proteomes, cellular transcriptomes and targeted metabolomics of five knockout mouse strains...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-09 | PXD035880 | Pride
Mitochondria Coenzyme q Lfq Mouse 
ProteomicsNeuronal metabolic rewiring promotesresilience to neurodegeneration caused by mitochondrial dysfunction
Neurodegeneration in mitochondrial disorders is considered irreversible because of limited metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial dysfunction for neuronal metabolism in vivo are poorly understood. Here, we profiled the cell-specific proteome of Purkinj...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-03 | PXD019690 | Pride
Anaplerosis Labe-free Tmt Purkinje neurons Mitofusin 2 
ProteomicsTEFM regulates both transcription elongation and RNA processing in mitochondria
Regulation of replication and expression of mitochondrial DNA (mtDNA) is essential for cellular energy conversion via oxidative phosphorylation. The mitochondrial transcription elongation factor (TEFM) has been proposed to regulate the switch between transcription termination for replication primer ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-04-25 | PXD013398 | Pride
Mtdna replication Rna processing Transcription elongation 
UnknownTargeting of the MYCN protein with small molecule c-MYC inhibitors.
Not available
S-EPMC4032254 | biostudies-literature
ProteomicsHigh levels of TFAM repress in vivo transcription of mitochondrial DNA
Mammalian mitochondrial DNA (mtDNA) is coated with mitochondrial transcription factor A (TFAM) and compacted into nucleoids. TFAM is not only the main component of mitochondrial nucleoids but its levels can also control mtDNA copy number. Here we show that the TFAM-to-mtDNA ratio is critical for mai...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-18 | PXD023050 | Pride
Transcription Tmt Dna Tfam Mitochondria 
UnknownHigh levels of TFAM repress mammalian mitochondrial DNA transcription in vivo.
Not available
S-EPMC8408345 | biostudies-literature
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